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. 2023 Mar;46(3):273-279.
doi: 10.1111/jfd.13742. Epub 2022 Dec 23.

Case series: Lymphoid neoplasia in three elasmobranch species

Karen R Archer  1 , Tanja Groll  2   3 , Richard J Harvey  1 , Sue M Thornton  1 , Mark F Stidworthy  1 , Daniela Denk  1
Affiliations

Case series: Lymphoid neoplasia in three elasmobranch species

Karen R Archer et al. J Fish Dis. 2023 Mar.

Abstract

Elasmobranchs (sharks and rays) are charismatic cartilaginous fish, popular in public aquaria. Almost 200 shark and ray species are listed as threatened by the International Union for Conservation of Nature (IUCN), demonstrating the importance of captive breeding and research programmes. Limited studies investigate diseases of elasmobranchs in captive and free-living environments, and among available literature neoplasia is rarely reported, with even fewer cases of lymphoid neoplasia documented. This article outlines the first reports of lymphoid neoplasia in three elasmobranch species in which haematopoietic neoplasms have not been reported to date. It summarizes signalment, history and histopathologic findings in an undulate ray, Raja undulata (Lacepede), a common smooth-hound, Mustelus mustelus (Linnaeus) and a bat ray, Myliobatis californica (Gill). Lesions were confirmed in a wide range of tissues and evidence of lymphoid leukaemia was seen in two cases. This small-scale review demonstrates that lymphoid neoplasia should be considered as a differential diagnosis in elasmobranchs presenting with lethargy and anorexia and highlights the challenges of immunohistochemical work up.

Keywords: elasmobranch; immunohistochemistry; lymphoma; neoplasia; ray; shark.

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References

REFERENCES

    1. Akirav, E. M., Alonso-Gonzalez, N., Truman, L. A., & Ruddle, N. H. (2012). Lymphoid tissues and organs. In W. E. Paul (Ed.), Fundamental immunology (7th ed., pp. 22-46). Lippincott Williams & Wilkins.
    1. Albuquerque, T. A. F., Drummond do Val, L., Doherty, A., & de Magalhães, J. P. (2018). From humans to hydra: Patterns of cancer across the tree of life. Biological Reviews, 93(3), 1715-1734. https://doi.org/10.1111/brv.12415
    1. Anders, K., & Yoshimizu, M. (1994). Role of viruses in the induction of skin tumours and tumour-like proliferations of fish. Diseases of Aquatic Organisms, 19(3), 215-232. https://doi.org/10.3354/dao019215
    1. Bjørgen, H., & Koppang, E. O. (2021). Anatomy of teleost fish immune structures and organs. Immunogenetics, 73(1), 53-63. https://doi.org/10.1007/s00251-020-01196-0
    1. Bowser, P. R., Casey, J. W., Wooster, G. A., Getchell, R. G., Chen, C. Y., & Chittum, L. (2002). Lymphosarcoma in hatchery-reared yearling tiger muskellunge. Journal of Aquatic Animal Health, 14(3), 225-229. https://doi.org/10.1577/1548-8667(2002)014<0225:LIHRYT>2.0.CO;2

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