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Review
. 2023 Sep 1;42(5):508-513.
doi: 10.1097/PGP.0000000000000925. Epub 2022 Sep 20.

Adult Granulosa Cell Tumour With Heterologous Adipocytic Differentiation: Report of a Unique Case

Liliana A L De Angelo Andrade, Melissa Alame, Nathalène Truffaux, Sabrina Croce, Ayla W Reis Queiroz, W Glenn McCluggage
Review

Adult Granulosa Cell Tumour With Heterologous Adipocytic Differentiation: Report of a Unique Case

Liliana A L De Angelo Andrade et al. Int J Gynecol Pathol. .

Abstract

Adult granulosa cell tumor is the most common malignant ovarian sex cord-stromal tumor and heterologous elements, in the form of hepatocytes or mucinous epithelium, have rarely been described in these neoplasms. Here, we report an adult granulosa cell tumor in a 61-year-old woman with classic and luteinized elements and exhibiting a previously unreported feature in the form of foci of mature adipocytes. In reporting this case, we review heterologous adipocytic elements and other heterologous elements in ovarian sex cord-stromal tumors and speculate on the pathogenesis of the adipocytic differentiation.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Young RH, Prat J, Scully RE. Ovarian Sertoli-Leydig cell tumors with heterologous elements. I. Gastrointestinal epithelium and carcinoid: a clinicopathologic analysis of thirty-six cases. Cancer 1982;50:2448–56.
    1. Prat J, Young RH, Scully RE. Ovarian Sertoli-Leydig cell tumors with heterologous elements. II. Cartilage and skeletal muscle: a clinicopathologic analysis of twelve cases. Cancer 1982;50:2465–75.
    1. Young RH. Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems. Mod Pathol 2005;18(suppl 2):S81–98.
    1. Nogales FF, Concha A, Plata C, et al. Granulosa cell tumor of the ovary with diffuse true hepatic differentiation simulating stromal luteinization. Am J Surg Pathol 1993;17:85–90.
    1. Ahmed E, Young RH, Scully RE. Adult granulosa cell tumor of the ovary with foci of hepatic cell differentiation: a report of four cases and comparison with two cases of granulosa cell tumor with Leydig cells. Am J Surg Pathol 1999;23:1089–93.