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Review
. 2023 Jan:241:154274.
doi: 10.1016/j.prp.2022.154274. Epub 2022 Dec 13.

A review on the role of LINC00152 in different disorders

Soudeh Ghafouri-Fard  1 , Arian Askari  2 , Bashdar Mahmud Hussen  3 , Mohammed Fatih Rasul  4 , Mohammad Taheri  5 , Arda Kiani  6
Affiliations
Review

A review on the role of LINC00152 in different disorders

Soudeh Ghafouri-Fard et al. Pathol Res Pract. 2023 Jan.

Abstract

LINC00152 is an important lncRNA in human disorders. It is mainly regarded as a tumor-promoting lncRNA. Mechanistically, LINC00152 serves as a molecular sponge for miR-143a-3p, miR-125a-5p, miR-139, miR-215, miR-193a/b-3p, miR-16-5p, miR-206, miR-195, miR-138, miR-185-5p, miR-103, miR-612, miR-150, miR-107, miR-205-5p and miR-153-3p. In addition, it can regulate activity of mTOR, EGFR/PI3K/AKT, ERK/MAPK, Wnt/β-Catenin, EGFR, NF-κB, HIF-1 and PTEN. In this review, we provide a concise but comprehensive explanation about the role of LINC00152 in tumor development and progression as well as its role in the pathology of non-malignant conditions with the aim of facilitating the clinical implementation of this lncRNA as a diagnostic or prognostic tumor marker and therapeutic target.

Keywords: Biomarker; Cancer; LINC00152.

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Conflict of interest statement

Competing interest The authors declare they have no conflict of interest.

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