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Comment
. 2023 Feb;39(2):83-85.
doi: 10.1016/j.pt.2022.12.003. Epub 2022 Dec 21.

Finding optimal drug target sites in parasite pathogens

Matthew Bogyo  1
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Comment

Finding optimal drug target sites in parasite pathogens

Matthew Bogyo. Trends Parasitol. 2023 Feb.

Abstract

Benns et al. have recently combined a chemoproteomic profiling method with a CRISPR-based gene-editing method to identify chemically targetable residues essential for fitness in the parasite Toxoplasma gondii. The result is a strategy that enables rapid discovery of new drug targets to combat T. gondii and other related parasites.

Keywords: CRISPR-mediated gene editing; Plasmodium falciparum; Toxoplasma gondii; activity-based protein profiling; chemoproteomics; cysteine reactivity.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

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