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Review
. 2023 Feb;21(1):32-44.
doi: 10.1007/s11914-022-00772-5. Epub 2022 Dec 24.

Update on the Role of Glucocorticoid Signaling in Osteoblasts and Bone Marrow Adipocytes During Aging

Husam Bensreti  1 , Dima W Alhamad  1 , Alejandro Marrero Gonzalez  1 , Manuel Pizarro-Mondesir  1 , Wendy B Bollag  2   3 , Carlos M Isales  4   5   6 , Meghan E McGee-Lawrence  7   8
Affiliations
Review

Update on the Role of Glucocorticoid Signaling in Osteoblasts and Bone Marrow Adipocytes During Aging

Husam Bensreti et al. Curr Osteoporos Rep. 2023 Feb.

Abstract

Purpose of review: Bone marrow adipose tissue (BMAT) in the skeleton likely plays a variety of physiological and pathophysiological roles that are not yet fully understood. In elucidating the complex relationship between bone and BMAT, glucocorticoids (GCs) are positioned to play a key role, as they have been implicated in the differentiation of bone marrow mesenchymal stem cells (BMSCs) between osteogenic and adipogenic lineages. The purpose of this review is to illuminate aspects of both endogenous and exogenous GC signaling, including the influence of GC receptors, in mechanisms of bone aging including relationships to BMAT.

Recent findings: Harmful effects of GCs on bone mass involve several cellular pathways and events that can include BMSC differentiation bias toward adipogenesis and the influence of mature BMAT on bone remodeling through crosstalk. Interestingly, BMAT involvement remains poorly explored in GC-induced osteoporosis and warrants further investigation. This review provides an update on the current understanding of the role of glucocorticoids in the biology of osteoblasts and bone marrow adipocytes (BMAds).

Keywords: BMAT; BMAd; BMSC; Dexamethasone; Glucocorticoid; Osteoporosis.

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Figures

Figure 1:
Figure 1:
Reported effects of exogenous and endogenous GC on bone marrow stem cells differentiation into osteoblast and adipocyte lineages. Figure created with BioRender.com.
See this image and copyright information in PMC

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