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. 2023 Mar;182(3):1077-1081.
doi: 10.1007/s00431-022-04770-8. Epub 2022 Dec 24.

Hearing screening test in neonates born to COVID-19-positive mothers

Anastasios Goulioumis  1 , Maria Angelopoulou  2 , Konstantinos Kourelis  2 , Konstantinos Mourtzouchos  2 , Magdalini Tsiakou  2 , Athanasios Asimakopoulos  2
Affiliations

Hearing screening test in neonates born to COVID-19-positive mothers

Anastasios Goulioumis et al. Eur J Pediatr. 2023 Mar.

Abstract

SARS-CoV-2, the responsible virus for the COVID-19 pandemic, has demonstrated neurotropic properties indicated by cases presenting with auditory and vestibular system insults. The expression of ACE-2 receptors in the placenta and the detection of IgM antibodies against the virus in the fetuses of pregnant women suffering from COVID-19 render vertical transmission of the infection to the fetus possible. Thus, our study aims to examine whether, similar to other viruses like CMV, SARS-CoV-2 is responsible for congenital hearing loss. This is a retrospective study in a regional pediatric hospital. The medical records of newborns (n = 111) born by mothers positive for COVID-19 during pregnancy who underwent screening hearing tests with Transient Evoked Otoacoustic Emissions (TEOAE) and Automatic Auditory Brainstem Response (AABR) from February 2020 to June 2022 were reviewed. Neonates with additional aggravating factors for congenital hearing loss were excluded from the study. For the study period, nine mothers were found positive during the first trimester, twenty mothers in the second trimester, and eighty-three mothers in the third trimester. TEOAEs test and AABR test scored PASS bilaterally in all neonates tested.

Conclusion: Infection with COVID-19 during pregnancy was not a risk factor for hearing loss, similar to other studies.

What is known: • The pathogenetic mechanism of the viral-induced impairment of the organ of Corti includes direct damage to the hair cells and indirect damage due to the induction of the innate inflammatory response. • Early data suggested that the SARS-CoV-2 virus also has neurotropic properties with manifestations from the sensory epithelia.

What is new: • Although the intrauterine infection remains controversial, the expression of the ACE-2 receptor on the placenta and the detection of IgM antibodies, as well as the covid-19 genome in fetuses, make the vertical transmission tenable. • In our study, the newborn hearing screening results indicate that COVID-19 infection during pregnancy is not a risk factor for hearing loss.

Keywords: COVID-19; Congenital hearing loss; Screening audiology tests; TEOAEs.

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Conflict of interest statement

The authors declare no competing interests.

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