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Review
. 2023 Mar;50(3):2901-2908.
doi: 10.1007/s11033-022-08149-8. Epub 2022 Dec 24.

Genetic advances in Meniere Disease

Qingqing Dai #  1   2 , Lili Long #  3 , Hui Zhao  4 , Ruikai Wang  5 , Hong Zheng  1 , Maoli Duan  6
Affiliations
Review

Genetic advances in Meniere Disease

Qingqing Dai et al. Mol Biol Rep. 2023 Mar.

Abstract

Meniere Disease (MD) is an idiopathic inner ear disease with complex etiology and pathogenesis, which is still unclear. With the development in gene analysis technology, the genetic research of MD has attracted extensive attention, resulting in a large number of studies on the research of the relationship between human genes and MD. This paper aims to review the studies on this topic in recent years. The studies mainly focused on the genetics of familial MD and the correlation between MD and potentially related functional genes. The results of these studies have demonstrated the complexity and diversity of the pathogenesis of MD with both genetic and epigenetic alterations, suggesting that MD might be related to inflammation, immunity, aqua and ion balance in the lymphatic fluid, virus infection, metabolism, and abnormal function of nerve conduction. The finding of rare mutations in TECTA, MYO7A and OTOG genes and other genes such as CDH23, PCDH15 and ADGRV1 in the same families suggest that the integrity of the stereocilia and their interaction with the tectorial and otolithic membranes could be involved in the pathophysiology of familial MD.

Keywords: Etiology; Gene; Meniere Disease; Pathogenesis.

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Conflict of interest statement

The authors declare that they have no conflict of interest either financial or non-financial.

References

    1. Campbell CA, Della Santina CC, Meyer NC, et al. Polymorphisms in KCNE1 or KCNE3 are not associated with Meniere disease in the Caucasian population. Am J Med Genet A. 2010;152A:67–74. - PubMed
    1. Teresa R, Sonia C, Carmen MS, et al. Identification of two novel mutations in FAM136A and DTNA genes in autosomal-dominant familial Meniere’s disease. Hum Mol Genet. 2015;24:1119–1126. - PMC - PubMed
    1. Martin-Sierra C, Requena T, Frejo L, et al. A novel missense variant in PRKCB segregates low-frequency hearing loss in an autosomal dominant family with Meniere’s disease. Hum Mol Genet. 2016;25:3407–3415. - PMC - PubMed
    1. Martín-Sierra C, Gallego-Martinez A, Requena T, et al. Variable expressivity and genetic heterogeneity involving DPT and SEMA3D genes in autosomal dominant familial Meniere’s disease. Eur J Hum Genet. 2017;25:200–207. - PMC - PubMed
    1. Roman-Naranjo P, Parra-Perez AM, Escalera-Balsera A, et al. Defective alpha-tectorin may involve tectorial membrane in familial Meniere disease. Clin Transl Med. 2022;12:e829. - PMC - PubMed