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Editorial
. 2022 Dec 24;14(24):9775-9776.
doi: 10.18632/aging.204456. Epub 2022 Dec 24.

Leveraging pathway analysis in a human skin model of healthy aging

Dimitrios Tsitsipatis  1 , Myriam Gorospe  1 , Allison B Herman  1
Affiliations
Editorial

Leveraging pathway analysis in a human skin model of healthy aging

Dimitrios Tsitsipatis et al. Aging (Albany NY). .
No abstract available

Keywords: GESTALT; network analysis; primary skin fibroblasts; proteomics; skin aging.

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Figures

Figure 1
Figure 1
Leveraging Pathway Analysis in a Human Skin Model of Healthy Aging. Primary fibroblast cultures were established from skin biopsies of individuals within the GESTALT study of healthy aging (NIA, NIH), and their proteomes were analyzed by mass spectrometry. Although the expression levels of individual proteins varied across donors within the same age group, the activities of pathways in which these proteins participate were highly consistent. Hence, we propose that interventions aimed at restoring the function of pathways (instead of the function of individual proteins) may be more effective in preventing age-associated declines in older tissues.
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