Cutoff Values of MASK-air Patient-Reported Outcome Measures

Bernardo Sousa-Pinto¹, Ana Sá-Sousa¹, Rafael José Vieira¹, Rita Amaral¹, Ana Margarida Pereira¹, Josep M Anto², Ludger Klimek³, Wienczyslawa Czarlewski⁴, Joaquim Mullol⁵, Oliver Pfaar⁶, Anna Bedbrook⁷, Luisa Brussino⁸, Violeta Kvedariene⁹, Desirée E Larenas-Linnemann¹⁰, Yoshitaka Okamoto¹¹, Maria Teresa Ventura¹², Ignacio J Ansotegui¹³, Sinthia Bosnic-Anticevich¹⁴, G Walter Canonica¹⁵, Victoria Cardona¹⁶, Lorenzo Cecchi¹⁷, Tomas Chivato¹⁸, Cemal Cingi¹⁹, Elísio M Costa²⁰, Alvaro A Cruz²¹, Stefano Del Giacco²², Philippe Devillier²³, Wytske J Fokkens²⁴, Bilun Gemicioglu²⁵, Tari Haahtela²⁶, Juan Carlos Ivancevich²⁷, Piotr Kuna²⁸, Igor Kaidashev²⁹, Helga Kraxner³⁰, Daniel Laune³¹, Renaud Louis³², Michael Makris³³, Riccardo Monti³⁴, Mario Morais-Almeida³⁵, Ralph Mösges³⁶, Marek Niedoszytko³⁷, Nikolaos G Papadopoulos³⁸, Vincenzo Patella³⁹, Nhân Pham-Thi⁴⁰, Frederico S Regateiro⁴¹, Sietze Reitsma²⁴, Philip W Rouadi⁴², Boleslaw Samolinski⁴³, Aziz Sheikh⁴⁴, Milan Sova⁴⁵, Luis Taborda-Barata⁴⁶, Sanna Toppila-Salmi²⁶, Joaquin Sastre⁴⁷, Ioanna Tsiligianni⁴⁸, Arunas Valiulis⁴⁹, Arzu Yorgancioglu⁵⁰, Mihaela Zidarn⁵¹, Torsten Zuberbier⁵², Joao A Fonseca¹, Jean Bousquet⁵³

Affiliations

¹ MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal; CINTESIS-Center for Health Technology and Services Research, University of Porto, Porto, Portugal; RISE-Health Research Network, University of Porto, Porto, Portugal.
² Department of Research & Development, ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain; Department of Medical Research & Environment, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; Department of Epidemiology of Asthma, Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
³ Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany; Center for Rhinology and Allergology, Wiesbaden, Germany.
⁴ Medical Consulting Czarlewski, Levallois and MASK-air, Montpellier, France.
⁵ Rhinology Unit and Smell Clinic, ENT Department, Hospital Clínic, Clinical and Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain.
⁶ Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
⁷ Department of Allergy, ARIA & MASK-air, Montpellier, France.
⁸ Department of Medical Sciences, Allergy and Clinical Immunology Unit, University of Torino and Mauriziano Hospital, Torino, Italy.
⁹ Department of Pathology, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; Institute of Clinical Medicine, Clinic of Chest Diseases and Allergology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
¹⁰ Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico.
¹¹ Department of Otorhinolaryngology, Chiba University Hospital and Chiba Rosai Hospital, Chiba, Japan.
¹² Unit of Geriatric Immunoallergology, University of Bari Medical School and Institute of Sciences of Food Production, National Research Council (Ispa-Cnr), Bari, Italy.
¹³ Department of Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain.
¹⁴ Quality Use of Respiratory Medicines Group, Woolcock Institute of Medical Research, Sydney, Sydney Pharmacy School, The University of Sydney, Sydney Local Health District, Sydney, NSW, Australia.
¹⁵ Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy; Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Italy.
¹⁶ Allergy Section, Department of Internal Medicine, Hospital Vall d'Hebron & ARADyAL research network, Barcelona, Spain.
¹⁷ SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy.
¹⁸ School of Medicine, University CEU San Pablo, Madrid, Spain.
¹⁹ ENT Department, Eskisehir Osmangazi University, Medical Faculty, Eskisehir, Turkey.
²⁰ UCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing of University of Porto (Porto4Ageing), Porto, Portugal.
²¹ Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Bahia, Brazil.
²² Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology, University Hospital "Duilio Casula", University of Cagliari, Cagliari, Italy.
²³ VIM Suresnes, UMR 0892, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France.
²⁴ Department of Otorhinolaryngology, Amsterdam University Medical Centres, AMC, Amsterdam, the Netherlands.
²⁵ Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
²⁶ Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
²⁷ Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina.
²⁸ Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.
²⁹ Department of Internal Medicine, Poltava State Medical University, Poltava, Ukraine.
³⁰ Department of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University, Budapest, Hungary.
³¹ Department Recherches & Développement, KYomed INNOV, Montpellier, France.
³² Department of Pulmonary Medicine, CHU Liege, and GIGA I3 research group, University of Liege, Liege, Belgium.
³³ Allergy Unit "D Kalogeromitros", 2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece.
³⁴ Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario A Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
³⁵ Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal.
³⁶ IMSB, Medical Faculty, University at Cologne, and ClinCompetence Cologne GmbH, Cologne, Germany.
³⁷ Department of Allergology, Medical University of Gdańsk, Gdansk, Poland.
³⁸ Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
³⁹ Division of Allergy and Clinical Immunology, Department of Medicine, Agency of Health ASL Salerno, "Santa Maria della Speranza" Hospital, Battipaglia, Salerno, Italy.
⁴⁰ Ecole Polytechnique Palaiseau, IRBA (Institut de Recherche bio-Médicale des Armées), Bretigny, France.
⁴¹ Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Institute of Immunology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Coimbra Institute for Clinical and Biomedical Research (ICBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
⁴² Department of Otolaryngology-Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon; Department of Otolaryngology-Head and Neck Surgery, Dar Al Shifa Hospital, Salmiya, Kuwait.
⁴³ Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Poland.
⁴⁴ Usher Institute, the University of Edinburgh, Edinburgh, UK.
⁴⁵ Department of Respiratory Medicine and Tuberculosis, University Hospital, Brno, Czech Republic.
⁴⁶ UBIAir-Clinical & Experimental Lung Centre, University of Beira Interior, Covilhã and CICS-Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal; Department of Immunoallergology, Cova da Beira University Hospital Centre, Covilhã, Portugal.
⁴⁷ Fundacion Jimenez Diaz, CIBERES, Faculty of Medicine, Autonoma University of Madrid, Madrid, Spain.
⁴⁸ Health Planning Unit, Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece; International Primary Care Respiratory Group IPCRG, Aberdeen, Scotland.
⁴⁹ Institute of Clinical Medicine and Institute of Health Sciences, Vilnius, Lithunia; Medical Faculty of Vilnius University, Vilnius, Lithuania.
⁵⁰ Department of Pulmonary Diseases, Celal Bayar University, Faculty of Medicine, Manisa, Turkey.
⁵¹ University Clinic of Respiratory and Allergic Diseases, Golnik & University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia.
⁵² Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany.
⁵³ Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany; Department of Pneumology, University Hospital, Montpellier, France. Electronic address: jean.bousquet@orange.fr.

PMID: 36566778
DOI: 10.1016/j.jaip.2022.12.005

Cutoff Values of MASK-air Patient-Reported Outcome Measures

Bernardo Sousa-Pinto et al. J Allergy Clin Immunol Pract. 2023 Apr.

. 2023 Apr;11(4):1281-1289.e5.

doi: 10.1016/j.jaip.2022.12.005. Epub 2022 Dec 22.

Authors

Affiliations

¹ MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal; CINTESIS-Center for Health Technology and Services Research, University of Porto, Porto, Portugal; RISE-Health Research Network, University of Porto, Porto, Portugal.
² Department of Research & Development, ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain; Department of Medical Research & Environment, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; Department of Epidemiology of Asthma, Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
³ Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany; Center for Rhinology and Allergology, Wiesbaden, Germany.
⁴ Medical Consulting Czarlewski, Levallois and MASK-air, Montpellier, France.
⁵ Rhinology Unit and Smell Clinic, ENT Department, Hospital Clínic, Clinical and Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain.
⁶ Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
⁷ Department of Allergy, ARIA & MASK-air, Montpellier, France.
⁸ Department of Medical Sciences, Allergy and Clinical Immunology Unit, University of Torino and Mauriziano Hospital, Torino, Italy.
⁹ Department of Pathology, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; Institute of Clinical Medicine, Clinic of Chest Diseases and Allergology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
¹⁰ Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico.
¹¹ Department of Otorhinolaryngology, Chiba University Hospital and Chiba Rosai Hospital, Chiba, Japan.
¹² Unit of Geriatric Immunoallergology, University of Bari Medical School and Institute of Sciences of Food Production, National Research Council (Ispa-Cnr), Bari, Italy.
¹³ Department of Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain.
¹⁴ Quality Use of Respiratory Medicines Group, Woolcock Institute of Medical Research, Sydney, Sydney Pharmacy School, The University of Sydney, Sydney Local Health District, Sydney, NSW, Australia.
¹⁵ Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy; Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Italy.
¹⁶ Allergy Section, Department of Internal Medicine, Hospital Vall d'Hebron & ARADyAL research network, Barcelona, Spain.
¹⁷ SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy.
¹⁸ School of Medicine, University CEU San Pablo, Madrid, Spain.
¹⁹ ENT Department, Eskisehir Osmangazi University, Medical Faculty, Eskisehir, Turkey.
²⁰ UCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing of University of Porto (Porto4Ageing), Porto, Portugal.
²¹ Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Bahia, Brazil.
²² Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology, University Hospital "Duilio Casula", University of Cagliari, Cagliari, Italy.
²³ VIM Suresnes, UMR 0892, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France.
²⁴ Department of Otorhinolaryngology, Amsterdam University Medical Centres, AMC, Amsterdam, the Netherlands.
²⁵ Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
²⁶ Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
²⁷ Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina.
²⁸ Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.
²⁹ Department of Internal Medicine, Poltava State Medical University, Poltava, Ukraine.
³⁰ Department of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University, Budapest, Hungary.
³¹ Department Recherches & Développement, KYomed INNOV, Montpellier, France.
³² Department of Pulmonary Medicine, CHU Liege, and GIGA I3 research group, University of Liege, Liege, Belgium.
³³ Allergy Unit "D Kalogeromitros", 2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece.
³⁴ Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario A Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
³⁵ Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal.
³⁶ IMSB, Medical Faculty, University at Cologne, and ClinCompetence Cologne GmbH, Cologne, Germany.
³⁷ Department of Allergology, Medical University of Gdańsk, Gdansk, Poland.
³⁸ Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
³⁹ Division of Allergy and Clinical Immunology, Department of Medicine, Agency of Health ASL Salerno, "Santa Maria della Speranza" Hospital, Battipaglia, Salerno, Italy.
⁴⁰ Ecole Polytechnique Palaiseau, IRBA (Institut de Recherche bio-Médicale des Armées), Bretigny, France.
⁴¹ Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Institute of Immunology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Coimbra Institute for Clinical and Biomedical Research (ICBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
⁴² Department of Otolaryngology-Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon; Department of Otolaryngology-Head and Neck Surgery, Dar Al Shifa Hospital, Salmiya, Kuwait.
⁴³ Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Poland.
⁴⁴ Usher Institute, the University of Edinburgh, Edinburgh, UK.
⁴⁵ Department of Respiratory Medicine and Tuberculosis, University Hospital, Brno, Czech Republic.
⁴⁶ UBIAir-Clinical & Experimental Lung Centre, University of Beira Interior, Covilhã and CICS-Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal; Department of Immunoallergology, Cova da Beira University Hospital Centre, Covilhã, Portugal.
⁴⁷ Fundacion Jimenez Diaz, CIBERES, Faculty of Medicine, Autonoma University of Madrid, Madrid, Spain.
⁴⁸ Health Planning Unit, Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece; International Primary Care Respiratory Group IPCRG, Aberdeen, Scotland.
⁴⁹ Institute of Clinical Medicine and Institute of Health Sciences, Vilnius, Lithunia; Medical Faculty of Vilnius University, Vilnius, Lithuania.
⁵⁰ Department of Pulmonary Diseases, Celal Bayar University, Faculty of Medicine, Manisa, Turkey.
⁵¹ University Clinic of Respiratory and Allergic Diseases, Golnik & University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia.
⁵² Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany.
⁵³ Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany; Department of Pneumology, University Hospital, Montpellier, France. Electronic address: jean.bousquet@orange.fr.

PMID: 36566778
DOI: 10.1016/j.jaip.2022.12.005

Abstract

Background: In clinical and epidemiological studies, cutoffs of patient-reported outcome measures can be used to classify patients into groups of statistical and clinical relevance. However, visual analog scale (VAS) cutoffs in MASK-air have not been tested.

Objective: To calculate cutoffs for VAS global, nasal, ocular, and asthma symptoms.

Methods: In a cross-sectional study design of all MASK-air participants, we compared (1) approaches based on the percentiles (tertiles or quartiles) of VAS distributions and (2) data-driven approaches based on clusters of data from 2 comparators (VAS work and VAS sleep). We then performed sensitivity analyses for individual countries and for VAS levels corresponding to full allergy control. Finally, we tested the different approaches using MASK-air real-world cross-sectional and longitudinal data to assess the most relevant cutoffs.

Results: We assessed 395,223 days from 23,201 MASK-air users with self-reported allergic rhinitis. The percentile-oriented approach resulted in lower cutoff values than the data-driven approach. We obtained consistent results in the data-driven approach. Following the latter, the proposed cutoff differentiating "controlled" and "partly-controlled" patients was similar to the cutoff value that had been arbitrarily used (20/100). However, a lower cutoff was obtained to differentiate between "partly-controlled" and "uncontrolled" patients (35 vs the arbitrarily-used value of 50/100).

Conclusions: Using a data-driven approach, we were able to define cutoff values for MASK-air VASs on allergy and asthma symptoms. This may allow for a better classification of patients with rhinitis and asthma according to different levels of control, supporting improved disease management.

Keywords: Asthma; Conjunctivitis; Cutoffs; MASK-air; Rhinitis.

PubMed Disclaimer

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Cutoff Values of MASK-air Patient-Reported Outcome Measures

Affiliations

Cutoff Values of MASK-air Patient-Reported Outcome Measures

Authors

Affiliations

Abstract

Publication types

MeSH terms