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. 2022;71(11):2352-2357.
doi: 10.1007/s11172-022-3662-4. Epub 2022 Dec 19.

Luminescent polyelectrolytes with antiviral activity

E F Panarin  1 , A I Fischer  1   2 , N A Nesterova  1 , A A Shtro  3 , A V Dobrodumov  1 , I I Gavrilova  1 , V A Manakhov  3 , T N Nekrasova  1
Affiliations

Luminescent polyelectrolytes with antiviral activity

E F Panarin et al. Russ Chem Bull. 2022.

Abstract

Radical polymerization was used to synthesize and characterize (co)polymers with sodium styrenesulfonate (NaSS), 4-methacryloylamidosalicylic acid (MASA), and N-vinylpyrrolidone, which have a low cytotoxicity and a high antiviral activity against the human respiratory syncytial virus. The interaction of copolymers with Tb3+ ions was studied. The complexes formed in dilute aqueous solutions at a concentration of MASA units c ⩽ 1 · 10-4 mol L-1 demonstrate a strong luminescence. The luminescence intensity is independent of copolymer composition, but increases when the NaSS units are substituted with uncharged N-vinylpyrrolidone units. The obtained Tb3+ polymer complexes are promising luminescent sensors for the visualization of biological objects interacting with copolymers.

Keywords: 4-methacryloylamidosalicylic acid; antiviral activity; lanthanides; luminescent metal-polymer complexes; sodium polystyrenesulfonate.

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