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. 2022 Dec 9:13:1038975.
doi: 10.3389/fneur.2022.1038975. eCollection 2022.

Causal association between adiponectin and the risk of Alzheimer's disease: A Mendelian randomization study

Tianyu Jin  1   2 , Wei Huang  3 , Fangzheng Cao  1 , Xinyue Yu  4 , Zhenhua Ying  3 , Shunyuan Guo  2 , Yifan Cheng  2 , Chao Xu  2
Affiliations

Causal association between adiponectin and the risk of Alzheimer's disease: A Mendelian randomization study

Tianyu Jin et al. Front Neurol. .

Abstract

Background: Numerous observational studies have revealed that circulating adiponectin (ADPN) is associated with Alzheimer's disease (AD) risk. However, the causality remains unknown. We aimed to assess the causality of circulating ADPN on AD risk using Mendelian randomization (MR).

Methods: Fourteen single nucleotide polymorphisms (SNPs) significantly associated with ADPN were selected from publicly available genetic abstract data. We applied these SNPs to two recent large-scale genome-wide association studies (GWAS) of AD, one from the FinnGen consortium and the other from a large meta-analysis. The inverse variance weighted method, MR-Egger method, the weighted median method, the Cochran Q statistic, the MR-Pleiotropy Residual Sum and Outlier methods, and the leave-one-out analysis were applied for MR analyses.

Results: In MR analysis, no significant genetic association was found between plasma ADPN levels and AD risk by analyzing the FinnGen consortium GWAS database in the inverse variance weighted method [odds ratio (OR): 0.874, 95% confidence interval (CI): 0.701-1.089, p = 0.230], MR-Egger (OR: 0.944, 95% CI: 0.692-1.288, p = 0.721), and weighted median method (OR: 0.900, 95% CI: 0.678-1.194, p = 0.449). Additionally, the same analysis was conducted for the meta-analysis database, and we found no significant association (OR: 1.000, 95% CI: 0.999-1.001, p = 0.683).

Conclusion: Our findings reveal no significant causal association between circulating ADPN and AD risk.

Keywords: Alzheimer's disease; Mendelian randomization; adiponectin; causality; risk.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
An overview of the study design. SNP, single nucleotide polymorphism; IVs, instrumental variables.
Figure 2
Figure 2
MR results and sensitivity analysis for association of ADPN and AD. IVW, inverse variance weighted.
See this image and copyright information in PMC

References

    1. Gale SA, Acar D, Daffner KR. Dementia. Am J Med. (2018) 131:1161–9. 10.1016/j.amjmed.2018.01.022 - DOI - PubMed
    1. Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP. The global prevalence of dementia: A systematic review and metaanalysis. Alzheimer's Dem. (2013) 9:63–75. 10.1016/j.jalz.2012.11.007 - DOI - PubMed
    1. Baumgart M, Snyder HM, Carrillo MC, Fazio S, Kim H, Johns H. Summary of the evidence on modifiable risk factors for cognitive decline and dementia: a population-based perspective. Alzheimer Dem. (2015) 11:718–26. 10.1016/j.jalz.2015.05.016 - DOI - PubMed
    1. Jia L, Du Y, Chu L, Zhang Z, Li F, Lyu D, et al. . Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in china: a cross-sectional study. Lancet Public health. (2020) 5:e661–71. 10.1016/S2468-2667(20)30185-7 - DOI - PubMed
    1. Silva MVF, Loures CMG, Alves LCV, de Souza LC, Borges KBG, Carvalho MDG. Alzheimer's disease: risk factors and potentially protective measures. J Biomed Sci. (2019) 26:33. 10.1186/s12929-019-0524-y - DOI - PMC - PubMed

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