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. 2023 Jun;75(2):557-562.
doi: 10.1007/s12070-022-03367-9. Epub 2022 Dec 17.

COVID Associated Invasive Aspergillosis

Sudhir Bhandari  1 , Shubhangi Gupta  2 , Shruti Bhargava  3 , Sunil Samdani  2 , Shashank Nath Singh  2 , Bharat Bhushan Sharma  1 , Bharti Malhotra  4 , Meenu Bargrhatta  5 , Srikant Sharma  1 , Aruna Vyas  4 , Vishnu Sharma  1 , Mohnish Grover  2
Affiliations

COVID Associated Invasive Aspergillosis

Sudhir Bhandari et al. Indian J Otolaryngol Head Neck Surg. 2023 Jun.

Abstract

To study the possible association between invasive fungal sinusitis (aspergillosis) and coronavirus disease. An observational study was conducted at a tertiary care centre over 6 months, involving all patients with aspergillosis of the paranasal sinuses suffering from or having a history of COVID-19 infection. 92 patients presented with aspergillosis, all had an association with COVID-19 disease. Maxillary sinus (100%) was the most common sinus affected. Intraorbital extension was seen in 34 cases, while intracranial extension was seen in 5 cases. Diabetes mellitus was present in 75 of 92 cases. All had a history of steroid use during their coronavirus treatment. New manifestations of COVID-19 are appearing over time. The association between coronavirus and aspergillosis of the paranasal sinuses must be given serious consideration. Uncontrolled diabetes and overzealous use of steroids are two main factors aggravating the illness, and both of these must be properly checked.

Keywords: Aspergillosis; COVID associated aspergillosis; COVID-19; Diabetes mellitus; Paranasal sinuses; Steroid.

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Conflict of interest statement

Conflict of interestAll the authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
a–c Coronal, non-contrast computed tomography scans of the paranasal sinuses, showing involvement of the sinuses
Fig. 2
Fig. 2
a–c Coronal and axial Gadolinium enhanced magnetic resonance imaging scans of paranasal sinus, orbit and brain showing involvement of all sinuses along with extension into orbit and brain
See this image and copyright information in PMC

References

    1. Ranjan R, Sharma A, Verma MK. Characterization of the second wave of COVID-19 in India. medRxiv. 2021;1:1–10.
    1. Lancet E. India’s COVID-19 emergency. Lancet. 2021;397:1683. doi: 10.1016/S0140-6736(21)01052-7. - DOI - PMC - PubMed
    1. Sharma S, Grover M, Bhargava S, Samdani S, Kataria T. Post coronavirus disease mucormycosis: a deadly addition to the pandemic spectrum. J Laryngol Otol. 2021;8:1–6. - PMC - PubMed
    1. García-Reija MF, Crespo-Pinilla JI, Labayru-Echeveria C, Espeso-Ferrero A, Verrier-Hernández A. Invasive maxillary aspergillosis: report of a case and review of the literature. Med Oral. 2002;7:200–205. - PubMed
    1. Barclay L, Lie D. Diagnosis of allergic fungal rhinosinusitis clarified. Arch Oto Laryngol Head Neck Surg. 2006;132:173–178. doi: 10.1001/archotol.132.2.173. - DOI - PubMed

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