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Review
. 2023 Jan;27(1):11-17.
doi: 10.1007/s11916-022-01099-7. Epub 2022 Dec 26.

Treating Chronic Pain with Deep Brain Stimulation

Hao Tan  1 , Erin A Yamamoto  1 , Mohammed A Elkholy  2 , Ahmed M Raslan  3
Affiliations
Review

Treating Chronic Pain with Deep Brain Stimulation

Hao Tan et al. Curr Pain Headache Rep. 2023 Jan.

Abstract

Purpose of review: Deep brain stimulation (DBS) for chronic pain has been controversial. Despite the discouraging outcomes from multicenter clinical trial in the twentieth century, there is sustained interest in optimizing its use to improve patient outcomes. Here we provide a concise overview of DBS for chronic pain as a reference for clinicians.

Recent findings: Recently published data lends tentative support for DBS as a means of treating chronic pain. Still, high level-of-evidence data remain elusive. There are a handful of ongoing and prospective clinical trials exploring DBS for pain in the context of closed-loop neuromodulation, invasive electroencephalography monitoring, stimulation parameters, and novel intracranial targets. DBS is a potentially viable method of treating chronic pain. Procedure success is dependent on a number of factors including proper patient and intracranial target selection. Outcomes for ongoing and future clinical trials will help clinicians refine DBS use for this clinical indication.

Keywords: Chronic pain; DBS; Deep brain stimulation; Neuromodulation.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
    1. Iskandar BJ, Nashold BS Jr. History of functional neurosurgery. Neurosurg Clin N Am. 1995;6(1):1–25. - DOI
    1. Melzack R, Wall PD. Pain mechanisms: a new theory. Science. 1965;150(3699):971–9. - DOI
    1. Shealy CN, Mortimer JT, Reswick JB. Electrical inhibition of pain by stimulation of the dorsal columns: preliminary clinical report. Anesth Analg. 1967;46(4):489–91. - DOI
    1. Hariz MI, Blomstedt P, Zrinzo L. Deep brain stimulation between 1947 and 1987: the untold story. Neurosurg Focus. 2010;29(2):E1. - DOI
    1. •• Bittar RG, Kar-Purkayastha I, Owen SL, Bear RE, Green A, Wang S, et al. Deep brain stimulation for pain relief: a meta-analysis. J Clin Neurosci. 2005;12(5):515–9. Only meta-analysis of DBS for chronic pain within the literature. - DOI

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