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Published Erratum
. 2023 Jan:87:104399.
doi: 10.1016/j.ebiom.2022.104399. Epub 2022 Dec 24.

Corrigendum to Cao W, Shi M, Wu L, et al. "A renal-cerebral-peripheral sympathetic reflex mediates insulin resistance in chronic kidney disease" EBioMedicine. 2018 Nov;37:281-293

Wei Cao  1 , Meng Shi  1 , Liling Wu  1 , Zhichen Yang  1 , Xiaobing Yang  1 , Hongfa Liu  1 , Xin Xu  1 , Youhua Liu  1 , Christopher S Wilcox  2 , Fan Fan Hou  3
Affiliations
Published Erratum

Corrigendum to Cao W, Shi M, Wu L, et al. "A renal-cerebral-peripheral sympathetic reflex mediates insulin resistance in chronic kidney disease" EBioMedicine. 2018 Nov;37:281-293

Wei Cao et al. EBioMedicine. 2023 Jan.
No abstract available

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Figures

Fig. 4
Fig. 4
CKD in rats activates the cerebral RAS and TH expression via signals from the innervated kidney and adipose tissue that are enhanced by high dietary salt. (a–e) Central RAS expression in sham and 5/6Nx rats with normal- or high-salt intake. Renal denervation (RDX), denervation of epididymal adipose tissue (Epi DN), or deafferentation of epididymal adipose tissue with resiniferatoxin (Epi RTX) downregulates expression of central RAS in the subfornical organ (SFO) and paraventricular nucleus (PVN): representative photos of immunohistochemistry staining (a), quantitation of AGT or Ang II-positive cells (b&c), mRNA levels of AGT (d), and the protein levels of Ang II in brain (e). (f) Expression of tyrosine hydroxylase (TH) in c-fos positive neurons in rostral ventrolateral medulla (RVLM). (g) Expression of Nox2 in brain. Scale bar = 100 μm. Data are expressed as mean ± SD (n = 6 in each group). Effects of salt-loading in all panels are significantly higher in 5/6Nx rats than sham-operated rats (two-way ANOVA P < 0.05). ∗P < 0.05 vs 5/6Nx rats on normal-salt diet, #P < 0.05 vs 5/6Nx rats on high-salt diet by unpaired t test. Epi Saline, injection of vehicle (saline) into bilateral epididymal fat pads.
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