Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Mar;200(5):e44-e47.
doi: 10.1111/bjh.18620. Epub 2022 Dec 26.

Impaired respiratory function reduces haemoglobin oxygen affinity in COVID-19

Collaborators, Affiliations

Impaired respiratory function reduces haemoglobin oxygen affinity in COVID-19

Gaetano Bergamaschi et al. Br J Haematol. 2023 Mar.
No abstract available

Keywords: COVID-19; PaO2 to fraction of inspired oxygen ratio; SARS-CoV-2; haemoglobin P50; haemoglobin-oxygen affinity; oxyhaemoglobins.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Distribution of observed and predicted SO2 values in COVID‐19 patients. (A) SO2 is reported as a function of observed PaO2. and (B) as a function of PaO2 corrected for arterial blood pH and PaCO2. Red marks represent the expected SO2 value for any given PaO2 according to Doyle equation; blue dots correspond to experimental data.

References

    1. Liu W, Li H. COVID‐19: Attacks the 1‐beta chain of hemoglobin and captures the porphyrin to inhibit human heme metabolism. ChemRxiv. 2020. 10.26434/chemrxiv.11938173.v7 - DOI
    1. Daniel Y, Hunt BJ, Retter A, Henderson K, Wilson S, Sharpe CC, et al. Haemoglobin oxygen affinity in patients with severe COVID‐19 infection. Br J Haematol. 2020;190(3):e126–7. 10.1111/bjh.16888 - DOI - PMC - PubMed
    1. Vogel DJ, Formenti F, Retter AJ, Vasques F, Camporota L. A left shift in the oxyhaemoglobin dissociation curve in patients with severe coronavirus disease 2019 (COVID‐19). Br J Haematol. 2020;191(3):390–3. 10.1111/bjh.17128 - DOI - PMC - PubMed
    1. Ceruti S, Minotti B, Glotta A, Biggiogero M, Bona G, Marzano M, et al. temporal changes in the oxyhemoglobin dissociation curve of critically Ill COVID‐19 patients. J Clin Med. 2022;11(3):788. 10.3390/jcm11030788 - DOI - PMC - PubMed
    1. Valle A, Rodriguez J, Camiña F, Rodriguez‐Segade M, Ortola JB, Rodriguez‐Segade S. The oxyhaemoglobin dissociation curve is generally left‐shifted in COVID‐19 patients at admission to hospital, and this is associated with lower mortality. Br J Haematol. 2022;199(3):332–8. 10.1111/bjh.18431 - DOI - PMC - PubMed

Publication types