. 2023 Jun;32(6):1609-1619.

doi: 10.1007/s11136-022-03331-8. Epub 2022 Dec 26.

The relative contribution of co-morbidities to health-related quality of life of people with idiopathic pulmonary fibrosis using the Assessment of Quality of Life-8-Dimension multi-attribute utility instrument

Qiang Zheng^{1

2

3}, Ingrid A Cox^{1

2}, Barbara de Graaff^{1

2}, Julie A Campbell¹, Tamera J Corte^{2

4

5}, Ian Glaspole^{2

6

7}, Vidya Navaratnam^{8

9}, Peter Hopkins^{2

10

11}, Chris Zappala¹², Hasnat Ahmad^{1

13}, Ting Zhao¹, Sacha Macansh⁸, E Haydn Walters^#^{1

2

14}, Andrew J Palmer^#^{15

16}

Affiliations

¹ Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, 7001, Australia.
² NHMRC Centre of Research Excellence for Pulmonary Fibrosis, Camperdown, NSW, Australia.
³ Department of Anaesthesiology (High-Tech Branch), the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
⁴ Central Clinical School, The University of Sydney, Camperdown, Australia.
⁵ Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
⁶ Department of Allergy and Respiratory Medicine, The Alfred Hospital, Melbourne, Australia.
⁷ Faculty of Medicine, Monash University, Melbourne, Australia.
⁸ Australian Idiopathic Pulmonary Fibrosis Registry, Lung Foundation of Australia, Camperdown, NSW, Australia.
⁹ Queensland Lung Transplant Service, The Prince Charles Hospital, Brisbane, Australia.
¹⁰ Queensland Centre for Pulmonary Transplantation and Vascular Disease, The Prince Charles Hospital, Chermside, Australia.
¹¹ Faculty of Medicine, University of Queensland, Queensland, Australia.
¹² Department of Thoracic Medicine, Royal Brisbane & Women's Hospital, Brisbane, QLD, Australia.
¹³ Australian Government Department of Health and Aged Care, Tasmania (TAS) Office, Australia.
¹⁴ School of Medicine, University of Tasmania, Hobart, TAS, Australia.
¹⁵ Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, 7001, Australia. andrew.palmer@utas.edu.au.
¹⁶ NHMRC Centre of Research Excellence for Pulmonary Fibrosis, Camperdown, NSW, Australia. andrew.palmer@utas.edu.au.

^# Contributed equally.

PMID: 36572788
DOI: 10.1007/s11136-022-03331-8

The relative contribution of co-morbidities to health-related quality of life of people with idiopathic pulmonary fibrosis using the Assessment of Quality of Life-8-Dimension multi-attribute utility instrument

Qiang Zheng et al. Qual Life Res. 2023 Jun.

. 2023 Jun;32(6):1609-1619.

doi: 10.1007/s11136-022-03331-8. Epub 2022 Dec 26.

Authors

Affiliations

¹ Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, 7001, Australia.
² NHMRC Centre of Research Excellence for Pulmonary Fibrosis, Camperdown, NSW, Australia.
³ Department of Anaesthesiology (High-Tech Branch), the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
⁴ Central Clinical School, The University of Sydney, Camperdown, Australia.
⁵ Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
⁶ Department of Allergy and Respiratory Medicine, The Alfred Hospital, Melbourne, Australia.
⁷ Faculty of Medicine, Monash University, Melbourne, Australia.
⁸ Australian Idiopathic Pulmonary Fibrosis Registry, Lung Foundation of Australia, Camperdown, NSW, Australia.
⁹ Queensland Lung Transplant Service, The Prince Charles Hospital, Brisbane, Australia.
¹⁰ Queensland Centre for Pulmonary Transplantation and Vascular Disease, The Prince Charles Hospital, Chermside, Australia.
¹¹ Faculty of Medicine, University of Queensland, Queensland, Australia.
¹² Department of Thoracic Medicine, Royal Brisbane & Women's Hospital, Brisbane, QLD, Australia.
¹³ Australian Government Department of Health and Aged Care, Tasmania (TAS) Office, Australia.
¹⁴ School of Medicine, University of Tasmania, Hobart, TAS, Australia.
¹⁵ Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, 7001, Australia. andrew.palmer@utas.edu.au.
¹⁶ NHMRC Centre of Research Excellence for Pulmonary Fibrosis, Camperdown, NSW, Australia. andrew.palmer@utas.edu.au.

^# Contributed equally.

PMID: 36572788
DOI: 10.1007/s11136-022-03331-8

Abstract

Purpose: Little is known about the impact of co-morbidities on health-related quality of life (HRQoL) for people with idiopathic pulmonary fibrosis (IPF). We aimed to investigate the relative contribution of co-morbidities to HRQoL of people with IPF.

Methods: N = 157 participants were recruited from the Australian IPF Registry (AIPFR). Health state utilities (HSUs), and the super-dimensions of physical and psychosocial scores were measured using the Assessment of Quality of Life-8-Dimensions (AQoL-8D). The impact of co-morbidities on HRQoL was investigated using linear regression and general dominance analyses.

Results: A higher number of co-morbidities was associated with lower HSUs (p trend = 0.002). Co-morbidities explained 9.1% of the variance of HSUs, 16.0% of physical super-dimensional scores, and 4.2% of psychosocial super-dimensional scores. Arthritis was associated with a significant reduction on HSUs (β = - 0.09, 95% confidence interval [CI] - 0.16 to - 0.02), largely driven by reduced scores on the physical super-dimension (β = - 0.13, 95% CI - 0.20 to - 0.06). Heart diseases were associated with a significant reduction on HSUs (β = - 0.09, 95% CI - 0.16 to - 0.02), driven by reduced scores on physical (β = - 0.09, 95% CI - 0.16 to - 0.02) and psychosocial (β = -0.10, 95% CI - 0.17 to - 0.02) super-dimensions.

Conclusions: Co-morbidities significantly impact HRQoL of people with IPF, with markedly negative impacts on their HSUs and physical health. A more holistic approach to the care of people with IPF is important as better management of these co-morbidities could lead to improved HRQoL in people with IPF.

Keywords: AQoL-8D; Co-morbidity; Health-related quality of life; Idiopathic pulmonary fibrosis; Relative contribution.

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Cited by

Health-related quality of life and health state utility value in idiopathic pulmonary fibrosis: a systematic review and meta-analysis.
Zhao G, Lei S, Li Y, Feng Z, Li J. Zhao G, et al. Health Qual Life Outcomes. 2025 Jan 5;23(1):3. doi: 10.1186/s12955-024-02326-y. Health Qual Life Outcomes. 2025. PMID: 39757157 Free PMC article.

References

1. Tran, T., Šterclová, M., Mogulkoc, N., Lewandowska, K., Müller, V., Hájková, M., Kramer, M. R., Jovanović, D., Tekavec-Trkanjec, J., Studnicka, M., Stoeva, N., Hejduk, K., Dušek, L., Suissa, S., & Vašáková, M. (2020). The European MultiPartner IPF registry (EMPIRE): Validating long-term prognostic factors in idiopathic pulmonary fibrosis. Respiratory Research, 21(1), 1–11. - DOI
1. Strand, M. J., Sprunger, D., Cosgrove, G. P., Fernandez-Perez, E. R., Frankel, S. K., Huie, T. J., Olson, A. L., Solomon, J., Brown, K. K., & Swigris, J. J. (2014). Pulmonary function and survival in idiopathic vs secondary usual interstitial pneumonia. Chest, 146(3), 775–785. - DOI - PubMed - PMC
1. Cox, I. A., Otahal, P., Graaff, B., Corte, T. J., Moodley, Y., Zappala, C., Glaspole, I., Hopkins, P., Macansh, S., Walters, E. H., & Palmer, A. J. (2021). Incidence, prevalence and mortality of idiopathic pulmonary fibrosis in Australia. Respirology, 27(3), 209–216. - DOI - PubMed
1. Sheth, J. S., Xia, M., Murray, S., Martinez, C. H., Meldrum, C. A., Belloli, E. A., Salisbury, M. L., White, E. S., Holtze, C. H., & Flaherty, K. R. (2019). Frailty and geriatric conditions in older patients with idiopathic pulmonary fibrosis. Respiratory Medicine, 148, 6–12. - DOI - PubMed - PMC
1. Caminati, A., Lonati, C., Cassandro, R., Elia, D., Pelosi, G., Torre, O., Zompatori, M., Uslenghi, E., & Harari, S. (2019). Comorbidities in idiopathic pulmonary fibrosis: An underestimated issue. European Respiratory Review, 28(153), 190044. - DOI - PubMed - PMC

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The relative contribution of co-morbidities to health-related quality of life of people with idiopathic pulmonary fibrosis using the Assessment of Quality of Life-8-Dimension multi-attribute utility instrument

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The relative contribution of co-morbidities to health-related quality of life of people with idiopathic pulmonary fibrosis using the Assessment of Quality of Life-8-Dimension multi-attribute utility instrument

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