Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Apr;117(4):544-552.
doi: 10.1007/s12185-022-03522-6. Epub 2022 Dec 26.

Clinical features of complex karyotype in newly diagnosed acute myeloid leukemia

Shota Yoshida  1 , Masahiro Onozawa  2 , Naoki Miyashita  1 , Hiroyuki Kimura  1 , Shogo Takahashi  1 , Shota Yokoyama  1 , Toshihiro Matsukawa  1 , Shinsuke Hirabayashi  3 , Akio Mori  4 , Daisuke Hidaka  5 , Koichiro Minauchi  6 , Akio Shigematsu  7 , Junichi Hashiguchi  8 , Tetsuyuki Igarashi  9 , Yasutaka Kakinoki  10 , Yutaka Tsutsumi  11 , Makoto Ibata  12 , Hajime Kobayashi  13 , Yoshihito Haseyama  14 , Katsuya Fujimoto  15 , Toshimichi Ishihara  16 , Hajime Sakai  17 , Shuichi Ota  5 , Takeshi Kondo  4 , Takanori Teshima  1
Affiliations
Free article

Clinical features of complex karyotype in newly diagnosed acute myeloid leukemia

Shota Yoshida et al. Int J Hematol. 2023 Apr.
Free article

Abstract

Complex karyotype acute myeloid leukemia (CK-AML) has been classified as an adverse-risk subtype. Although a few reports have further classified CK-AML as typical (including monosomy of chromosomes 5, 7 and 17 or deletion of 5q, 7q and/or 17p) or atypical, the clinical features of these subtypes in Japanese patients remain unclear. We retrospectively analyzed a total of 115 patients with CK-AML, including 77 with typical CK-AML and 38 with atypical CK-AML. Median overall survival (OS) was significantly shorter in patients with typical CK-AML than atypical CK-AML (143 days vs. 369 days, P = 0.009). Among patients with typical CK-AML, those with monosomy 17 or deletion of 17p had significantly shorter OS than patients without such abnormalities (105 days vs. 165 days, P = 0.033). TP53 mutations were more predominant in patients with typical CK-AML than in patients with atypical CK-AML (69.7% vs. 32.4%, P < 0.001). Patients with typical CK-AML had a poor prognosis regardless of TP53 mutation status. Among patients with atypical CK-AML, however, prognosis was worse for those with the TP53 mutation than those without the mutation. In conclusion, prognosis is extremely poor for both typical CK-AML and atypical CK-AML with TP53 mutation.

Keywords: CK-AML; Complex karyotype; Deletion of 17p; Monosomy 17; TP53 mutation; Typical CK-AML.

PubMed Disclaimer

References

    1. Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P, Roberts ND, et al. Genomic classification and prognosis in acute myeloid leukemia. N Engl J Med. 2016;374(23):2209–21. https://doi.org/10.1056/NEJMoa1516192 . - DOI - PubMed - PMC
    1. Dohner H, Weisdorf DJ, Bloomfield CD. Acute myeloid leukemia. N Engl J Med. 2015;373(12):1136–52. https://doi.org/10.1056/NEJMra1406184 . - DOI - PubMed
    1. Kayser S, Levis MJ. Updates on targeted therapies for acute myeloid leukaemia. Br J Haematol. 2022;196(2):316–28. https://doi.org/10.1111/bjh.17746 . - DOI - PubMed
    1. Hasserjian RP, Steensma DP, Graubert TA, Ebert BL. Clonal hematopoiesis and measurable residual disease assessment in acute myeloid leukemia. Blood. 2020;135(20):1729–38. https://doi.org/10.1182/blood.2019004770 . - DOI - PubMed - PMC
    1. Liu H. Emerging agents and regimens for AML. J Hematol Oncol. 2021;14(1):49. https://doi.org/10.1186/s13045-021-01062-w . - DOI - PubMed - PMC

Substances