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. 2023 Apr;64(4):296-305.
doi: 10.1111/jsap.13583. Epub 2022 Dec 26.

Placenta-derived mesenchymal stromal cells as a treatment for refractory chronic gingivostomatitis in cats: eight cases (2018)

M Febre  1 , N Saulnier  1 , P Roux  2 , F Boutoille  3 , N Girard  4 , C Robert  1 , R Rakic  1 , E Rosset  5 , S Maddens  1
Affiliations

Placenta-derived mesenchymal stromal cells as a treatment for refractory chronic gingivostomatitis in cats: eight cases (2018)

M Febre et al. J Small Anim Pract. 2023 Apr.

Abstract

Objectives: The aim of this case series was to collect preliminary data on safety and efficacy of treating cats suffering from refractory feline chronic gingivostomatitis with a single intravenous therapy of cryopreserved placenta-derived mesenchymal stromal cells.

Materials and methods: We planned the prospective inclusion of cats suffering from refractory chronic gingivostomatitis in three veterinary clinics. All cats received a single infusion of 10×106 cryopreserved cells. Follow-up evaluations were done at day 15 and at 2-, 3- and 6-months following infusion. Clinical disease severity was evaluated by dental specialists using a published stomatitis disease activity index scoring system coupled with an owners' assessment questionnaire.

Results: All eight cats attended all follow up visits. Cryopreserved ready-to-use placenta-derived cells administered systemically were safe and resulted in notable clinical improvement in all cats as reported by stomatitis disease activity index scoring and owner's survey.

Clinical significance: Infusion of cryopreserved freshly thawed placenta-derived mesenchymal stromal cells appears to promote clinical and consequently behavioural benefits in cats with refractory chronic gingivostomatitis after having undergone full-mouth or premolar-molar tooth extraction. Future randomised studies are required to confirm safety and efficacy of this treatment.

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References

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    1. Arzi, B., Clark, K. C., Sundaram, A., et al. (2017) Therapeutic efficacy of fresh, allogeneic mesenchymal stem cells for severe refractory feline chronic gingivostomatitis: allogeneic stem cell therapy for feline oral inflammation. Stem Cells Translational Medicine 6, 1710-1722
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