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Comment
. 2023 Feb;79(2):283-286.
doi: 10.1007/s12020-022-03258-7. Epub 2022 Dec 27.

Looking at the spine in controlled Acromegaly

Maria Francesca Birtolo #  1   2 , Simone Antonini #  1   2 , Andrea G Lania  3   4 , Gherardo Mazziotti  5   6
Affiliations
Comment

Looking at the spine in controlled Acromegaly

Maria Francesca Birtolo et al. Endocrine. 2023 Feb.

Abstract

Skeletal fragility with high risk of vertebral fractures (VFs) is an emerging complication of growth hormone (GH) hypersecretion. VFs often coexist with spine arthropathy and both clinical conditions negatively impact on quality of life of acromegalic subjects. Management of spine osteopathy and arthropathy in acromegaly could be challenging since both complications can persist or even progress after biochemical control of disease. This article analyzes the latest evidence about possible pathophysiological links between VFs and spine arthropathy in active and controlled acromegaly, as well as the diagnostic and therapeutic aspects concerning the holistic management of acromegalic osteo-arthropathy.

Keywords: Acromegaly; Arthropathy; Osteopathy; Quality of life; Vertebral fractures.

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  • Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life.
    Cangiano B, Giusti E, Premoli C, Soranna D, Vitale G, Grottoli S, Cambria V, Mantovani G, Mungari R, Maffei P, Dassie F, Giampietro A, Chiloiro S, Tanda ML, Ippolito S, Cannavò S, Ragonese M, Zambon A, Persani L, Fatti LM, Scacchi M; “PRO-ACRO” study group on Motor Disability in Acromegaly, of the Italian Society of Endocrinology (SIE). Cangiano B, et al. Endocrine. 2022 Sep;77(3):510-518. doi: 10.1007/s12020-022-03106-8. Epub 2022 Jul 2. Endocrine. 2022. PMID: 35779206 Free PMC article.

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