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Review
. 2023 Feb:193:114673.
doi: 10.1016/j.addr.2022.114673. Epub 2022 Dec 24.

Recombinant protein-based injectable materials for biomedical applications

Cristobal Garcia Garcia  1 , Sai S Patkar  1 , Bin Wang  1 , Ramadan Abouomar  1 , Kristi L Kiick  2
Affiliations
Review

Recombinant protein-based injectable materials for biomedical applications

Cristobal Garcia Garcia et al. Adv Drug Deliv Rev. 2023 Feb.

Abstract

Injectable nanocarriers and hydrogels have found widespread use in a variety of biomedical applications such as local and sustained biotherapeutic cargo delivery, and as cell-instructive matrices for tissue engineering. Recent advances in the development and application of recombinant protein-based materials as injectable platforms under physiological conditions have made them useful platforms for the development of nanoparticles and tissue engineering matrices, which are reviewed in this work. Protein-engineered biomaterials are highly customizable, and they provide distinctly tunable rheological properties, encapsulation efficiencies, and delivery profiles. In particular, the key advantages of emerging technologies which harness the stimuli-responsive properties of recombinant polypeptide-based materials are highlighted in this review.

Keywords: Bioinspired materials; Drug delivery; Injectable hydrogels; Nanocarriers; Polypeptides; Recombinant proteins; Regenerative medicine; Stimuli-responsive polymers; Tissue engineering.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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