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. 2022 Dec 21:14:1783-1801.
doi: 10.2147/IJWH.S297062. eCollection 2022.

Management of Premenstrual Dysphoric Disorder: A Scoping Review

Sara V Carlini  1 , Teresa Lanza di Scalea  2 , Stephanie Trentacoste McNally  3 , Janice Lester  4 , Kristina M Deligiannidis  5
Affiliations

Management of Premenstrual Dysphoric Disorder: A Scoping Review

Sara V Carlini et al. Int J Womens Health. .

Abstract

Premenstrual dysphoric disorder (PMDD) and premenstrual syndrome (PMS) refer to physical, cognitive, or affective symptoms that arise in the late luteal phase and remit with menses. The present work is a clinically focused scoping review of the last twenty years of research on treatment for these disorders. A search of key terms using the PubMed/Medline, the Cochrane Library, Embase, and Web of Science databases was performed, and 194 studies of adult women met initial inclusion criteria for review. Research studies concerning medications, pharmacological and non-pharmacological complementary and alternative medicine treatments, and surgical interventions with the most available evidence were appraised and summarized. The most high-quality evidence can be found for the use of selective serotonin reuptake inhibitors (SSRIs) and combined oral contraceptives (COCs), with gonadotropin releasing hormone (GnRH) agonists and surgical interventions showing efficacy for refractory cases. While there is some evidence of the efficacy of alternative and complementary medicine treatments such as nutraceuticals, acupuncture, and yoga, variability in quality and methods of studies must be taken into account.

Keywords: disorder; disorders; dysphoria; dysphoric disorder; premenstrual syndrome; review; scoping; syndrome; treatment.

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Conflict of interest statement

Dr. Deligiannidis receives research funding from the National Institutes of Health (R01MH118269, R01MH120313) which supported her time for this research and manuscript. Dr. Deligiannidis has also received research funding from Sage Therapeutics, Inc. and Vorso Corporation (contracted research) and serves as a consultant to Sage Therapeutics, Inc., Brii Biosciences, GH Research, Ireland LLC and Brainify.AI. Dr. Carlini, Dr. Lanza di Scalea, Dr. McNally, and Ms. Lester have no disclosures to report for this work.

Figures

Figure 1
Figure 1
PRISMA flow diagram.
See this image and copyright information in PMC

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