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Comparative Study
. 1978 Dec;22(3):657-64.
doi: 10.1128/iai.22.3.657-664.1978.

Strain difference of delayed-type hypersensitivity to BCG and its genetic control in mice

Comparative Study

Strain difference of delayed-type hypersensitivity to BCG and its genetic control in mice

R M Nakamura et al. Infect Immun. 1978 Dec.

Abstract

Delayed-type hypersensitivity to BCG was remarkably different in two inbred strains of mice, SWM/Ms and C3H/He, when measured by the spleen index, the disappearance of peritoneal macrophage, or the footpad reaction. High responsiveness in the SWM/Ms strain appeared to be dominant over low responsiveness in the C3H/He strain. Results of the footpad reaction test if F1, F2, and backcross hybrids of these two strains of mice suggested that the delayed-type hypersensitivity was mainly controlled by a gene which was transmitted under Mendel's laws and was possibly non-H-2 linked. The spleen cells and their nylon wool nonadherent fraction from BCG-infected C3H/He mice were not reactive to purified protein derivative in vitro, whereas both the spleen cells and the nylon wool nonadherent fraction from BCG-infected SWM/Ms mice reacted well to purified protein derivative. Possible mechanisms of the different responses in the delayed-type hypersensitivity to BCG were discussed.

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References

    1. Immunology. 1963 May;6:264-75 - PubMed
    1. Immunology. 1968 May;14(5):707-11 - PubMed
    1. J Immunol. 1977 Jul;119(1):343-7 - PubMed
    1. Jpn J Med Sci Biol. 1978 Apr;31(2):143-54 - PubMed
    1. J Immunol. 1978 Jan;120(1):329-34 - PubMed

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