Strain difference of delayed-type hypersensitivity to BCG and its genetic control in mice
- PMID: 365763
- PMCID: PMC422210
- DOI: 10.1128/iai.22.3.657-664.1978
Strain difference of delayed-type hypersensitivity to BCG and its genetic control in mice
Abstract
Delayed-type hypersensitivity to BCG was remarkably different in two inbred strains of mice, SWM/Ms and C3H/He, when measured by the spleen index, the disappearance of peritoneal macrophage, or the footpad reaction. High responsiveness in the SWM/Ms strain appeared to be dominant over low responsiveness in the C3H/He strain. Results of the footpad reaction test if F1, F2, and backcross hybrids of these two strains of mice suggested that the delayed-type hypersensitivity was mainly controlled by a gene which was transmitted under Mendel's laws and was possibly non-H-2 linked. The spleen cells and their nylon wool nonadherent fraction from BCG-infected C3H/He mice were not reactive to purified protein derivative in vitro, whereas both the spleen cells and the nylon wool nonadherent fraction from BCG-infected SWM/Ms mice reacted well to purified protein derivative. Possible mechanisms of the different responses in the delayed-type hypersensitivity to BCG were discussed.
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