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Editorial
. 2023 Mar;19(3):237-240.
doi: 10.1080/1744666X.2023.2161512. Epub 2022 Dec 28.

Is there a role for the microbiome in systemic sclerosis?

Elizabeth R Volkmann  1
Affiliations
Editorial

Is there a role for the microbiome in systemic sclerosis?

Elizabeth R Volkmann. Expert Rev Clin Immunol. 2023 Mar.
No abstract available

Keywords: Microbiota; prebiotics; probiotics; systemic sclerosis.

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Figures

Figure 1.
Figure 1.
Microbiome-based interventions for SSc.
See this image and copyright information in PMC

References

    1. Ahn J, Hayes RB. Environmental Influences on the Human Microbiome and Implications for Noncommunicable Disease. Annu Rev Public Health 2021;42:277–92. - PMC - PubMed
    1. Hernández-Chirlaque C, Aranda CJ, Ocón B, et al. Germ-free and Antibiotic-treated Mice are Highly Susceptible to Epithelial Injury in DSS Colitis. J Crohns Colitis 2016;10:1324–35. - PubMed
    1. Volkmann ER, Hoffmann-Vold AM. Gastrointestinal tract microbiota modifications in systemic sclerosis. Eur J Rheumatol 2020;7:S228–36. - PMC - PubMed
    1. **Andréasson K, Lee SM, Lagishetty V, et al. Disease Features and Gastrointestinal Microbial Composition in Patients with Systemic Sclerosis from Two Independent Cohorts. ACR Open Rheumatol 2022;4:417–25. - PMC - PubMed

    2. This is the first study to demonstrate that patients with SSc with early disease (<3 years from the time of diagnosis) exhibit differences in gut microbial composition compared with healthy age- and gender-matched controls. This study also found that patients with unique disease features of SSc, such as ILD, exhibited similar microbial composition profiles.

    1. *Volkmann ER, Chang YL, Barroso N, et al. Association of Systemic Sclerosis with a Unique Colonic Microbial Consortium. Arthritis Rheumatol 2016;68:1483–92. - PMC - PubMed

    2. In the first study published on the gut microbiome in SSc, we demonstrated that patients with SSc had distinct differences in microbial composition compared with age- and gender-matched controls using colonic lavage specimens. This study also demonstrated that specific bacteria genera were associated with worsening GI symptoms in SSc.

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