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Review
. 2023 Mar 6;62(11):e202217840.
doi: 10.1002/anie.202217840. Epub 2023 Jan 16.

Stereochemical Editing

Guangying Tan  1 , Frank Glorius  1
Affiliations
Review

Stereochemical Editing

Guangying Tan et al. Angew Chem Int Ed Engl. .

Abstract

Stereochemical editing has recently risen to prominence, allowing the direct editing of organic molecules with stereocenter(s) to adjust their relative stereochemistry at a late-stage. Several seminal light-driven stereochemical editing reactions such as deracemization and epimerization have been successively developed. Recently, Wendlandt and co-workers reported a versatile photochemical epimerization of unactivated tertiary stereogenic centers to rapidly prepare the stereoisomers that were previously challenging to access.

Keywords: Deracemization; Epimerization; Photocatalysis; Stereochemical Editing; Stereoselective Synthesis.

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References

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