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. 2023 Jun;19(6):2450-2459.
doi: 10.1002/alz.12722. Epub 2022 Dec 28.

Srinivaspura Aging, Neuro Senescence and COGnition (SANSCOG) study: Study protocol

Vijayalakshmi Ravindranath  1 ; SANSCOG Study Team  1   2   3
Collaborators, Affiliations

Srinivaspura Aging, Neuro Senescence and COGnition (SANSCOG) study: Study protocol

Vijayalakshmi Ravindranath et al. Alzheimers Dement. 2023 Jun.

Abstract

Introduction: Prospective, population-based, aging, and cognition studies are an important approach to understand normal and pathological aging processes.

Methods: This is a longitudinal, community-based cohort study (n = 10,000) in rural India, with long-term follow-up for comprehensive evaluation of risk and protective factors associated with cognitive changes during aging. All participants will undergo comprehensive clinical, neurocognitive, and biochemical assessments. Genotyping using genome-wide association studies will be done for all participants. Whole genome sequencing and brain imaging (magnetic resonance imaging) will be done in a subset.

Results: This study will generate a rich database of clinical, neurocognitive, biochemical, neuroimaging, and genetic data that can help identify risk and protective factors for dementia and other related disorders.

Discussion: This longitudinal study is first of its kind, involving comprehensive evaluations, spanning phenotype to genotype, in a rural Indian cohort, and has major public health implications.

Keywords: India; aging; dementia; longitudinal cohort; methodology; prospective cohort; risk and protective factors; rural; study protocol.

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References

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