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Review
. 2023 Mar;43(3):534-545.
doi: 10.1111/liv.15501. Epub 2023 Jan 11.

Circadian rhythms and the liver

Rodolfo Costa  1   2   3 , Chiara Mangini  4 , Esther D Domenie  4 , Lisa Zarantonello  4 , Sara Montagnese  3   4
Affiliations
Review

Circadian rhythms and the liver

Rodolfo Costa et al. Liver Int. 2023 Mar.

Abstract

This narrative review briefly describes the mammalian circadian timing system, the specific features of the liver clock, also by comparison with other peripheral clocks, the role of the liver clock in the preparation of food intake, and its relationship with energy metabolism. It then goes on to provide a chronobiological perspective of the pathophysiology and management of several types of liver disease, with a particular focus on metabolic-associated fatty liver disease (MAFLD), decompensated cirrhosis and liver transplantation. Finally, it provides some insight into the potential contribution of circadian principles and circadian hygiene practices in preventing MAFLD, improving the prognosis of advanced liver disease and modulating liver transplantation outcomes.

Keywords: MAFLD; decompensated cirrhosis; liver clock; liver transplantation; mammalian circadian timing system; metabolism.

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References

REFERENCES

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