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Review
. 2023 Aug;29(8):e3474.
doi: 10.1002/psc.3474. Epub 2023 Jan 16.

Modulation of hydrogel networks by metal ions

Sara La Manna  1 , Daniele Florio  1 , Concetta Di Natale  2   3 , Daniela Marasco  1
Affiliations
Review

Modulation of hydrogel networks by metal ions

Sara La Manna et al. J Pept Sci. 2023 Aug.

Abstract

Self-assembling hydrogels are receiving great attention for both biomedical and technological applications. Self-assembly of protein/peptides as well as organic molecules is commonly induced in response to external triggers such as changes of temperature, concentration, or pH. An interesting strategy to modulate the morphology and mechanical properties of the gels implies the use of metal ions, where coordination bonds regulate the dynamic cross-linking in the construction of hydrogels, and coordination geometries, catalytic, and redox properties of metal ions play crucial roles. This review aims to discuss recent insights into the supramolecular assembly of hydrogels involving metal ions, with a focus on self-assembling peptides, as well as applications of metallogels in biomedical fields including tissue engineering, sensing, wound healing, and drug delivery.

Keywords: biomaterial; metal ion coordination; peptide hydrogels; self-recognition.

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References

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