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. 2023 Apr;65(4):865-870.
doi: 10.1007/s00234-022-03106-5. Epub 2022 Dec 29.

Congenital isolated unilateral third nerve palsy in children: the diagnostic contribution of high-resolution MR imaging

Filippo Arrigoni  1   2 , Luca Rombetto  3 , Daniela Redaelli  4 , Giorgio Mancarella  5 , Francesco Polenghi  4 , Roberto Salati  4 , Romina Romaniello  4 , Denis Peruzzo  4 , Paolo Emilio Bianchi  6 , Elena Piozzi  3 , Marco Mazza  3 , Adriano Magli  7
Affiliations

Congenital isolated unilateral third nerve palsy in children: the diagnostic contribution of high-resolution MR imaging

Filippo Arrigoni et al. Neuroradiology. 2023 Apr.

Abstract

Purpose: To describe the neuroanatomical correlates of unilateral congenital isolated oculomotor palsy by means of high-resolution MRI.

Methods: Children with a clinical diagnosis of congenital isolated oculomotr palsy and with a high-resolution MRI acquisition targeted on the orbits and cranial nerves were selected and included in the study. An experienced pediatric neuroradiologist evaluated all the exams, assessing the integrity and morphology of extraocular muscles, oculomotor, trochlear and abducens nerves as well as optic nerves and globes. Clinical data and ophthalmologic evaluations were also collected.

Results: Six children (age range: 1-16 years; males: 3) were selected. All patients showed, on the affected side (left:right = 5:1), anomalies of the III nerve and extraocular muscles innervated by the pathological nerve. One patient had complete nerve agenesis, two patients showed a diffuse thinning of the nerve, from the brainstem to the orbit and 3 patients showed a distal thinning of the oculomotor nerve, starting at the level of the cavernous sinus. In all cases atrophy of corresponding muscles was noticed, but the involvement of the affected muscles varied with the nervous pattern of injury.

Conclusions: High-resolution MRI represents a valuable tool for the diagnosis of III nerve anomalies in unilateral congenital IOP, showing different patterns of nerve involvement and muscular atrophy.

Keywords: Brain MRI; Children; Congenital cranial disinnervation disorders; Oculomotor nerve.

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