The Complex Interplay Between Antibiotic Resistance and Pharmaceutical and Personal Care Products in the Environment

Célia M Manaia¹, Diana S Aga², Eddie Cytryn³, William H Gaze⁴, David W Graham⁵, Jianhua Guo⁶, Anne F C Leonard⁴, Liguan Li⁷, Aimee K Murray⁴, Olga C Nunes⁸, Sara Rodriguez-Mozaz^{9

10}, Edward Topp^{11

12}, Tong Zhang⁷

Affiliations

¹ Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Porto, Portugal.
² Chemistry Department, University at Buffalo, The State University of New York, Buffalo, New York, USA.
³ Institute of Soil, Water and Environmental Sciences, Volcani Institute, Agricultural Research Organization, Rishon-Lezion, Israel.
⁴ European Centre for Environment and Human Health, University of Exeter Medical School, Penryn Campus, Cornwall, UK.
⁵ School of Engineering, Newcastle University, Newcastle, UK.
⁶ Australian Centre for Water and Environmental Biotechnology, The University of Queensland, St. Lucia, Queensland, Australia.
⁷ Environmental Microbiome Engineering and Biotechnology Laboratory, Department of Civil Engineering, The University of Hong Kong, The University of Hong Kong, Hong Kong, China.
⁸ Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Porto, Portugal.
⁹ Catalan Institute for Water Research, Girona, Spain.
¹⁰ Universitat de Girona, Girona, Spain.
¹¹ Agriculture and Agri-Food Canada, London, Ontario, Canada.
¹² Department of Biology, University of Western Ontario, London, Ontario, Canada.

PMID: 36582150
DOI: 10.1002/etc.5555

Review

The Complex Interplay Between Antibiotic Resistance and Pharmaceutical and Personal Care Products in the Environment

Célia M Manaia et al. Environ Toxicol Chem. 2024 Mar.

. 2024 Mar;43(3):637-652.

doi: 10.1002/etc.5555. Epub 2023 Feb 8.

Authors

Affiliations

¹ Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Porto, Portugal.
² Chemistry Department, University at Buffalo, The State University of New York, Buffalo, New York, USA.
³ Institute of Soil, Water and Environmental Sciences, Volcani Institute, Agricultural Research Organization, Rishon-Lezion, Israel.
⁴ European Centre for Environment and Human Health, University of Exeter Medical School, Penryn Campus, Cornwall, UK.
⁵ School of Engineering, Newcastle University, Newcastle, UK.
⁶ Australian Centre for Water and Environmental Biotechnology, The University of Queensland, St. Lucia, Queensland, Australia.
⁷ Environmental Microbiome Engineering and Biotechnology Laboratory, Department of Civil Engineering, The University of Hong Kong, The University of Hong Kong, Hong Kong, China.
⁸ Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Porto, Portugal.
⁹ Catalan Institute for Water Research, Girona, Spain.
¹⁰ Universitat de Girona, Girona, Spain.
¹¹ Agriculture and Agri-Food Canada, London, Ontario, Canada.
¹² Department of Biology, University of Western Ontario, London, Ontario, Canada.

PMID: 36582150
DOI: 10.1002/etc.5555

Abstract

Antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) are important environmental contaminants. Nonetheless, what drives the evolution, spread, and transmission of antibiotic resistance dissemination is still poorly understood. The abundance of ARB and ARGs is often elevated in human-impacted areas, especially in environments receiving fecal wastes, or in the presence of complex mixtures of chemical contaminants, such as pharmaceuticals and personal care products. Self-replication, mutation, horizontal gene transfer, and adaptation to different environmental conditions contribute to the persistence and proliferation of ARB in habitats under strong anthropogenic influence. Our review discusses the interplay between chemical contaminants and ARB and their respective genes, specifically in reference to co-occurrence, potential biostimulation, and selective pressure effects, and gives an overview of mitigation by existing man-made and natural barriers. Evidence and strategies to improve the assessment of human health risks due to environmental antibiotic resistance are also discussed. Environ Toxicol Chem 2024;43:637-652. © 2022 SETAC.

Keywords: Wastewater; environmental contaminants; horizontal gene transfer; risk assessment.

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References

REFERENCES

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The Complex Interplay Between Antibiotic Resistance and Pharmaceutical and Personal Care Products in the Environment

Affiliations

The Complex Interplay Between Antibiotic Resistance and Pharmaceutical and Personal Care Products in the Environment

Authors

Affiliations

Abstract

References

REFERENCES

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Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical