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Case Reports
. 2022 Nov 8:84:104834.
doi: 10.1016/j.amsu.2022.104834. eCollection 2022 Dec.

Rapidly progressive tumor stage mycosis fungoides: A case report from Syria

Yara Melhem  1 , Moatasem Hussein Al-Janabi  2 , Maha Mansour  3 , Hameed Suleman  1 , Zuheir Al-Shehabi  4
Affiliations
Case Reports

Rapidly progressive tumor stage mycosis fungoides: A case report from Syria

Yara Melhem et al. Ann Med Surg (Lond). .

Abstract

Introduction and importance: Mycosis Fungoides, the most common type of cutaneous T-cell lymphomas (CTCLs), has typically an indolent course over years or decades. Patches grow into infiltrated plaques which may turn eventually into tumors. The tumor stage represents advanced lymphoma, but this occurs in a minority (∼10%) of cases.

Case presentation: we present a rare case of mycosis fungoides in a 30-year-old woman showing rapid progression to tumor stage, unlike the indolent clinical course seen classically.

Clinical discussion: Mycosis Fungoides (MF) is the most common primary cutaneous T-cell lymphoma, representing less than 1% of the total number of non-Hodgkin lymphoma. Patients with a classical type of MF progress from patch stage to plaque stage and finally to tumor stage disease, and they have a protracted clinical course over years or even decades.

Conclusion: Although mycosis fungoides is a rare disease, it requires a high degree of suspicion clinically. The disease can have an excellent prognosis when identified and treated promptly.

Keywords: Mycosis fungoides; Primary cutaneous lymphoma; Tumor stage.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
Clinical image shows large nodules and tumors with scaly infiltrated plaques on axilla (A) and abdomen (B).
Fig. 2
Fig. 2
Hematoxylin-eosin staining (A–D) Microscopic images of Mycosis Fungoides. (A) Marked infiltration of malignant T-cells in the epidermis and dermis (x40). (B) Papillary dermal fibrosis is present (x100). (C) Atypical lymphoid cells surrounded by a clear halo in the epidermis are seen (x200). (D) Malignant cells are pleomorphic with irregular cerebriform nuclei (x400).
Fig. 3
Fig. 3
Immunohistochemical staining (A–D). (A and B) Tumor cells are positive for CD4 and CD3 respectively. (C and D) Tumor cells are negative for CD8 and CD20 respectively.
See this image and copyright information in PMC

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