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Review
. 2022 Dec 23:14:3551-3565.
doi: 10.2147/CMAR.S389591. eCollection 2022.

The Chemoprotective Role of Vitamin D in Skin Cancer: A Systematic Review

Eva Krishna Sutedja  1 , Tiara Rachmaputeri Arianto  1 , Ronny Lesmana  2 , Oki Suwarsa  1 , Budi Setiabudiawan  3
Affiliations
Review

The Chemoprotective Role of Vitamin D in Skin Cancer: A Systematic Review

Eva Krishna Sutedja et al. Cancer Manag Res. .

Abstract

Introduction: Research in mice showed that vitamin D receptor deficiency was correlated with an increased rate of non-melanoma skin cancer. Therapeutic supplemental vitamin D has also been reported to reduce cell growth in both melanoma and non-melanoma skin cancer. This paper aims to describe the existing research studies that discuss the potential and role of vitamin D in the management of skin cancer.

Methods: Articles were searched from three databases (PubMed, ScienceDirect, Scopus) and manual search. 18 articles were included. These were further divided into in vivo and in vitro studies. The literature search was based on the following Patients, Intervention, Control, and Outcome (PICO) criteria: Patients with any types of skin cancer; Vitamin D and their derivates as the intervention; placebo or standard regimen as control, and survival rate or response rate as primary outcome.

Results: From the three databases, we obtained 802 studies. Prior to screening of the literature obtained, several studies were excluded. In the eligibility assessment, seven studies were excluded due to their outcomes being not eligible for analysis, and two studies were excluded due to inaccessible full texts. The remaining 18 studies were included. Five studies had a clinical research design (randomized controlled trial or interventional study), which use vitamin D3 as vitamin D derivatives and the results showed that the administration of vitamin D3 reduces the proliferation of skin cancer cells. Similar results were also reported in studies with pre-clinical research designs, either in vivo or in vitro, where six were in vivo studies and nine studies were in vitro studies.

Conclusion: Our literature review revealed that that vitamin D derivatives, such as 1,25(OH)2D3 or 20(OH)D3 can effectively reduce the proliferation of skin cancer cells by contributing in the inhibition of cell growth and development, highlighting vitamin D's role as good prognostic factor.

Keywords: basal cell carcinoma; calciferol; melanoma; skin cancer; squamous cell carcinoma; vitamin D3.

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Conflict of interest statement

The authors declared no conflicts of interest related to this work.

Figures

Figure 1
Figure 1
Article selection for the systematic review on the potential role of calciferol for optimizing cancer therapy.
Figure 2
Figure 2
Role of vitamin D in skin cancer.
See this image and copyright information in PMC

References

    1. Mason RS, Reichrath J. Sunlight vitamin D and skin cancer. Anticancer Agents Med Chem. 2013;13(1):83–97. doi:10.2174/187152013804487272 - DOI - PubMed
    1. Purdue MP, Freeman LE, Anderson WF, et al. Recent trends in incidence of cutaneous melanoma among US Caucasian young adults. J Invest Dermatol. 2008;128:2905–2908. doi:10.1038/jid.2008.159 - DOI - PMC - PubMed
    1. Linos E, Swetter SM, Cockburn MG, et al. Increasing burden of melanoma in the United States. J Invest Dermatol. 2009;129:1666–1674. doi:10.1038/jid.2008.423 - DOI - PMC - PubMed
    1. Memon A, Bannister P, Rogers I, et al. Changing epidemiology and age-specific incidence of cutaneous malignant melanoma in England: an analysis of the national cancer registration data by age, gender and anatomical site, 1981–2018. Lancet Reg Health Eur. 2021;2:100024. doi:10.1016/j.lanepe.2021.100024 - DOI - PMC - PubMed
    1. Apalla Z, Lallas A, Sotiriou E, et al. Epidemiological trends in skin cancer. Dermatol Pract Concept. 2017;7(2):1–6. doi:10.5826/dpc.0702a01 - DOI - PMC - PubMed