Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Dec 13:16:1068114.
doi: 10.3389/fnins.2022.1068114. eCollection 2022.

Mesenchymal stem cells for regenerative medicine in central nervous system

Man Li  1 , Hong Chen  1 , Mingxin Zhu  2
Affiliations
Review

Mesenchymal stem cells for regenerative medicine in central nervous system

Man Li et al. Front Neurosci. .

Abstract

Mesenchymal stem cells (MSCs) are multipotent stem cells, whose paracrine and immunomodulatory potential has made them a promising candidate for central nervous system (CNS) regeneration. Numerous studies have demonstrated that MSCs can promote immunomodulation, anti-apoptosis, and axon re-extension, which restore functional neural circuits. The therapeutic effects of MSCs have consequently been evaluated for application in various CNS diseases including spinal cord injury, cerebral ischemia, and neurodegenerative disease. In this review, we will focus on the research works published in the field of mechanisms and therapeutic effects of MSCs in CNS regeneration.

Keywords: anti-apoptosis; central nervous system; immunomodulation; mesenchymal stem cells (MeSH ID D059630); regenerative medicine.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Schematic diagram of immunoregulatory properties of mesenchymal stem cells (MSCs).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Agadi S., Shetty A. K. (2015). Concise review: prospects of bone marrow mononuclear cells and mesenchymal stem cells for treating status epilepticus and chronic epilepsy. Stem Cells 33 2093–2103. 10.1002/stem.2029 - DOI - PMC - PubMed
    1. Ali I., Aertgeerts S., Le Blon D., Bertoglio D., Hoornaert C., Ponsaerts P., et al. (2017). Intracerebral delivery of the M2 polarizing cytokine interleukin 13 using mesenchymal stem cell implants in a model of temporal lobe epilepsy in mice. Epilepsia 58 1063–1072. 10.1111/epi.13743 - DOI - PubMed
    1. Babaei P., Soltani Tehrani B., Alizadeh A. (2012). Transplanted bone marrow mesenchymal stem cells improve memory in rat models of Alzheimer’s disease. Stem Cells Int. 2012:369417. 10.1155/2012/369417 - DOI - PMC - PubMed
    1. Bai L., Lennon D. P., Caplan A. I., DeChant A., Hecker J., Kranso J., et al. (2012). Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models. Nat. Neurosci. 15 862–870. 10.1038/nn.3109 - DOI - PMC - PubMed
    1. Bayat A. H., Saeidikhoo S., Ebrahimi V., Mesgar S., Joneidi M., Soltani R., et al. (2021). Bilateral striatal transplantation of human olfactory stem cells ameliorates motor function, prevents necroptosis-induced cell death and improves striatal volume in the rat model of Huntington’s disease. J. Chem. Neuroanat. 112:101903. 10.1016/j.jchemneu.2020.101903 - DOI - PubMed

LinkOut - more resources