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Review
. 2022 Dec 13:16:1068114.
doi: 10.3389/fnins.2022.1068114. eCollection 2022.

Mesenchymal stem cells for regenerative medicine in central nervous system

Man Li  1 , Hong Chen  1 , Mingxin Zhu  2
Affiliations
Review

Mesenchymal stem cells for regenerative medicine in central nervous system

Man Li et al. Front Neurosci. .

Abstract

Mesenchymal stem cells (MSCs) are multipotent stem cells, whose paracrine and immunomodulatory potential has made them a promising candidate for central nervous system (CNS) regeneration. Numerous studies have demonstrated that MSCs can promote immunomodulation, anti-apoptosis, and axon re-extension, which restore functional neural circuits. The therapeutic effects of MSCs have consequently been evaluated for application in various CNS diseases including spinal cord injury, cerebral ischemia, and neurodegenerative disease. In this review, we will focus on the research works published in the field of mechanisms and therapeutic effects of MSCs in CNS regeneration.

Keywords: anti-apoptosis; central nervous system; immunomodulation; mesenchymal stem cells (MeSH ID D059630); regenerative medicine.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Schematic diagram of immunoregulatory properties of mesenchymal stem cells (MSCs).
See this image and copyright information in PMC

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