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Case Reports
. 2022 Dec 1:31:133-136.
doi: 10.1016/j.jdcr.2022.11.025. eCollection 2023 Jan.

Palmoplantar keratoderma and digital clubbing in 2 sisters with hypertrophic osteoarthropathy

Daniel Eriksson  1 , David Gyll  2 , Marie Virtanen  3   4 , Niklas Dahl  1 , Joakim Klar  1 , Eva-Lena Stattin  1
Affiliations
Case Reports

Palmoplantar keratoderma and digital clubbing in 2 sisters with hypertrophic osteoarthropathy

Daniel Eriksson et al. JAAD Case Rep. .
No abstract available

Keywords: HPGD; HPGD, 15-hydroxyprostaglandin dehydrogenase; PHO, primary hypertrophic osteoarthropathy; PPK, palmoplantar keratoderma; digital clubbing; hereditary palmoplantar keratoderma; hyperhidrosis; hypertrophic osteoarthropathy.

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Conflict of interest statement

None disclosed.

Figures

Fig 1
Fig 1
Pedigree of the affected family. Black color marks subjects affected by palmoplantar keratoderma, digital clubbing, and hyperhidrosis.
Fig 2
Fig 2
A, Severe onycholysis affecting the subject’s right thumb nail. B, Notable digital clubbing. Keratoderma affecting the (C) left and (D) right palms.
See this image and copyright information in PMC

References

    1. Hedstrand H., Berglund G., Werner I. Keratoderma palmaris et plantaris with clubbing and skeletal deformity of the terminal phalanges of the hands and feet. Report of findings in two sisters. Acta Derm Venereol. 1972;52(4):278–280. - PubMed
    1. Sadeghi R., Zakavi S.R., Ghasemov M., Kakhki V.R.D. Age-related changes in skull uptake on bone scintigraphy: a quantitative study. Nucl Med Rev Cent East Eur. 2008;11(2):67–69. - PubMed
    1. Uppal S., Diggle C.P., Carr I.M., et al. Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy. Nat Genet. 2008;40(6):789–793. - PubMed
    1. Bergmann C., Wobser m., Morbach H., et al. Primary hypertrophic osteoarthropathy with digital clubbing and palmoplantar hyperhidrosis caused by 15-PGHD/HPGD loss-of-function mutations. Exp Dermatol. 2011;20(6):531–533. - PubMed
    1. Castori M., Sinibaldi L., Mingarelli R., Lachman R.S., Rimoin D.L., Dallapiccola B. Pachydermoperiostosis: an update. Clin Genet. 2005;68(6):477–486. - PubMed

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