Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Apr;68(4):1641-1652.
doi: 10.1007/s10620-022-07806-z. Epub 2022 Dec 30.

Sarcopenia Defined by Psoas Muscle Thickness Predicts Mortality After Transjugular Intrahepatic Portosystemic Shunt

Tongqiang Li #  1   2 , Jiacheng Liu #  1   2 , Jianbo Zhao #  3 , Yaowei Bai #  1   2 , Songjiang Huang  1   2 , Chongtu Yang  1   2 , Yingliang Wang  1   2 , Chen Zhou  1   2 , Chaoyang Wang  1   2 , Shuguang Ju  1   2 , Yang Chen  1   2 , Wei Yao  1   2 , Bin Xiong  4   5
Affiliations

Sarcopenia Defined by Psoas Muscle Thickness Predicts Mortality After Transjugular Intrahepatic Portosystemic Shunt

Tongqiang Li et al. Dig Dis Sci. 2023 Apr.

Abstract

Purpose: To assess and compare the value of psoas muscle thickness at the level of the third lumbar (L3) vertebra (TPML) or umbilicus (TPMU) and skeletal muscle index (SMI) for diagnosing sarcopenia and predicting mortality in patients undergoing transjugular intrahepatic portosystemic shunt (TIPS).

Materials and methods: Two hundred forty-nine patients undergoing TIPS were included in this retrospective study. The cut-offs of L3-SMI for sarcopenia were 42.0 cm2/m2 in men and 38.0 cm2/m2 in women. The cut-offs for TPML/height and TPMU/height to predict mortality was established using a receiver-operating characteristic analysis. The Kaplan-Meier and Cox regression were used for survival analyses.

Results: Compared with TPMU/height, TPML/height was more consistent with L3-SM for the diagnosis of sarcopenia (Kappa coefficient: 0.63 vs. 0.36 in men; 0.61 vs. 0.45 in women). The Cox analysis showed that both TPML/height and TPMU/height were independent risk factors for mortality. The optimal cut-off values of TPML/height and TPMU/height for mortality in men and women were 11.2 mm/m, 9.4 mm/m, 18.4 mm/m, 15.1 mm/m, respectively. There were 119 (47.8%), 87 (34.9%), and 82 (32.9%) patients diagnosed with sarcopenia in the TPMU/height, TPML/height, and L3-SMI models, respectively. Kaplan-Meier analysis showed that the overall survival was significantly lower in the sarcopenia group in all three models.

Conclusion: TPMU/height and TPML/height have a similar survival prognostic value as L3-SMI. TPML/height has better consistency with L3-SMI in diagnosing sarcopenia and is a more stable alternative to L3-SMI for diagnosing sarcopenia in patients undergoing TIPS.

Keywords: Mortality; Psoas muscles; Sarcopenia; Skeletal muscle; Transjugular intrahepatic portosystemic shunt.

PubMed Disclaimer

Comment in

Similar articles

See all similar articles

Cited by

References

    1. Lai JC, Tandon P, Bernal W et al. Malnutrition, frailty, and sarcopenia in patients with cirrhosis: 2021 practice guidance by the american association for the study of liver diseases. Hepatology. 2021;74:1611–1644. - DOI - PubMed
    1. Kim SE, Kim DJ. Sarcopenia as a prognostic indicator of liver cirrhosis. J Cachexia Sarcopenia Muscle. 2022;13:8–10. - DOI - PubMed
    1. Tantai X, Liu Y, Yeo YH et al. Effect of sarcopenia on survival in patients with cirrhosis: a meta-analysis. J Hepatol. 2022;76:588–599. - DOI - PubMed
    1. Tapper EB, Zhang P, Garg R et al. Body composition predicts mortality and decompensation in compensated cirrhosis patients: a prospective cohort study. JHEP Rep. 2020;2:100061. - DOI - PubMed
    1. Ando Y, Ishigami M, Ito T et al. Sarcopenia impairs health-related quality of life in cirrhotic patients. Eur J Gastroenterol Hepatol. 2019;31:1550–1556. - DOI - PubMed

Publication types

LinkOut - more resources