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Review
. 2023 Mar 31;68(6).
doi: 10.1088/1361-6560/acaf45.

Roadmap for precision preclinical x-ray radiation studies

Frank Verhaegen  1   2 , Karl T Butterworth  3 , Anthony J Chalmers  4 , Rob P Coppes  5 , Dirk de Ruysscher  1 , Sophie Dobiasch  6   7 , John D Fenwick  8 , Patrick V Granton  9 , Stefan H J Heijmans  10 , Mark A Hill  11 , Constantinos Koumenis  12 , Kirsten Lauber  13   14 , Brian Marples  15 , Katia Parodi  14   16 , Lucas C G G Persoon  10 , Nick Staut  2 , Anna Subiel  17 , Rianne D W Vaes  1 , Stefan van Hoof  2 , Ioannis L Verginadis  12 , Jan J Wilkens  6   18 , Kaye J Williams  19 , George D Wilson  20   21 , Ludwig J Dubois  22
Affiliations
Free article
Review

Roadmap for precision preclinical x-ray radiation studies

Frank Verhaegen et al. Phys Med Biol. .
Free article

Abstract

This Roadmap paper covers the field of precision preclinical x-ray radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technological evolution in imaging, irradiation, dosimetry and monitoring that have empowered these kinds of studies is discussed, and many developments in the near future are outlined. Finally, clinical translation and reverse translation are discussed.

Keywords: cancer models; dosimetry; imaging; irradiation; precision; preclinical; translation.

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