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. 2023 Feb:207:107098.
doi: 10.1016/j.rmed.2022.107098. Epub 2022 Dec 28.

How respiratory symptoms impact asthma-related quality of life in mild asthmatics

Gilles Louis  1 , Florence Schleich  2 , Renaud Louis  2 , Michèle Guillaume  3 , Bernardo Sousa-Pinto  4 , Jean Bousquet  5 , Benoit Pétré  3
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Free article

How respiratory symptoms impact asthma-related quality of life in mild asthmatics

Gilles Louis et al. Respir Med. 2023 Feb.
Free article

Abstract

Many studies exploring the factors associated with asthma-specific quality of life (QOL) have shown that asthma control is the main predictor of asthma-related QOL. However, to the best of our knowledge, no study has ever explored the individual impact of the five main symptoms of asthma (wheezing, dyspnea, chest tightness, cough and airway secretion) reported directly by the patient on asthma-related QOL. A cross-sectional study was conducted on untreated adult (≥18 years) asthmatics recruited from the Liege University Hospital Asthma Clinic (Belgium) for asthma diagnosis confirmation between 2018 and 2021 (n = 171). Multiple linear regression analysis demonstrated that dyspnea and chest tightness were the two leading factors associated with asthma-related QOL in a population of mild asthma.

Keywords: Asthma; PROM; Quality of life; Symptoms.

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Conflict of interest statement

Declaration of competing interest Outside of this submitted work, RL received unrestricted research grants from GSK, AstraZeneca, Novartis and Chiesi and lecture or adboard fees from GSK, AZ, Novartis and Sonafi. Outside of this submitted work, FS received lecture or adboard fees from Chiesi, AZ, GSK, and Novartis. Outside this submitted work, JB reports personal fees (member of advisory boards, consultations, honoraria for meeting lectures) from Cipla, Menarini, Mylan, Novartis, Purina, Sanofi‐Aventis, Teva, Uriach. Shareholder of KYomed Innov and MASK-air-SAS. The rest of the authors declare that they have no relevant conflicts of interest.

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