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. 2023 Feb:158:185-191.
doi: 10.1016/j.jpsychires.2022.12.021. Epub 2022 Dec 29.

Maternal expression of miR-let-7d-3p and miR-451a during gestation influences the neuropsychomotor development of 90 days old babies: "Pregnancy care, healthy baby" study

Fernanda Nedel  1 , Camila P Ferrúa  1 , Cainá C do Amaral  1 , Geovanna P Corrêa  1 , Roberta G Silveira  1 , Jéssica P Trettim  1 , Gabriela K da Cunha  1 , Adriana B Klug  1 , Ana Paula Ardais  1 , Tatiane B Fogaça  2 , Karen A T Pinheiro  3 , Rachel K S S Bast  4 , Gabriele Ghisleni  1 , Luciano D de M Souza  1 , Mariana B de Matos  1 , Luciana de A Quevedo  1 , Ricardo T Pinheiro  5
Affiliations

Maternal expression of miR-let-7d-3p and miR-451a during gestation influences the neuropsychomotor development of 90 days old babies: "Pregnancy care, healthy baby" study

Fernanda Nedel et al. J Psychiatr Res. 2023 Feb.

Abstract

Introduction: Studies on maternal microRNA expression have emerged to better understand regulatory mechanisms during the gestational period, since microRNA expression has been associated with pregnancy disorders.

Objectives: This study aims to investigate the association between the expression of the maternal microRNAs miR-let-7d-3p and miR-451a during the second gestational trimester and neuropsychomotor development at 90 days of life of infants.

Methods: This is a case-control study nested within a cohort, with the groups being divided into dyads in which pregnant women presented Major Depressive Episode (MDE) (n = 64), these being the cases, and their respective controls (no MDE; n = 64). The Bayley Scale III was used to assess the outcome of child development, and MDE was assessed through the Mini International Neuropsychiatric Interview Plus. The analysis of miR-let-7d-3p and miR-451a was done via serum from the pregnant women, utilizing the qRT-PCR (n = 128).

Results: The results indicated a negative association between expression levels of miR-451a (β -3.3 CI95% -6.4;-0.3) and a positive associated of the miR-let-7d-3p with the cognitive development domain (β 1.7 CI95% 0.1; 3.0), and a positive association between expression of miR-let-7d-3p with motor development of the infants (β 1.6 CI95% 0.3; 2.9).

Conclusion: This is a pioneering study on the topic that indicates a biological interrelationship between the miRNAs miR-let-7d-3p and miR-451a evaluated during the pregnancy and the motor and cognitive domains of infant development at 90 days postpartum.

Keywords: Cognitive development; Infant development; Motor development; Pregnancy; miR-451a; miR-let-7d-3p.

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Conflict of interest statement

Declaration of competing interest The authors have declared no conflict of interest. Ricardo Tavares Pinheiro.

Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
Scatter plot with miRNAs miR-let-7d-3p and miR-451a.
See this image and copyright information in PMC

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