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Review
. 2023 Feb 5:632:122571.
doi: 10.1016/j.ijpharm.2022.122571. Epub 2022 Dec 29.

A review on taste masked multiparticulate dosage forms for paediatric

Khater Al-Japairai  1 , Samah Hamed Almurisi  2 , Abd Almonem Doolaanea  3 , Syed Mahmood  4 , Fawaz Alheibshy  5 , Ahmed Alobaida  6 , Nadiya Abdul-Halim  7 , Bappaditya Chatterjee  8
Affiliations
Review

A review on taste masked multiparticulate dosage forms for paediatric

Khater Al-Japairai et al. Int J Pharm. .

Abstract

Taste refers to those sensations perceived through taste buds on the tongue and oral cavity. The unpleasant taste of drugs leads to the refusal of taking the medicine in the paediatric population. It is widely known that a pharmaceutical product's general acceptability is the result of numerous contributing components such as swallowability, palatability (taste, flavour, texture, and mouthfeel), appearance, ease of administration, and patient characteristics. Multiparticulate as a dosage form is a platform technology for overcoming paediatrics' incapacity to swallow monolithic dosage forms, masking many medications' inherent nasty taste, and overcoming the obstacles of manufacturing a commercially taste masked dosage form. This review will discuss the considerations that must be taken into account to prepare taste masked multiparticulate dosage forms in the best way for paediatric use.

Keywords: Multiparticulate system; Paediatric; Taste masking; Unpleasant drug.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.