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. 2023 Mar;46(3):170-172.
doi: 10.1016/j.tins.2022.12.003. Epub 2022 Dec 30.

Transposable elements and Alzheimer's disease pathogenesis

Teresa H Evering  1 , Jez L Marston  1 , Li Gan  2 , Douglas F Nixon  3
Affiliations

Transposable elements and Alzheimer's disease pathogenesis

Teresa H Evering et al. Trends Neurosci. 2023 Mar.

Abstract

Alzheimer's disease (AD) is characterized by the pathological accumulation of amyloid β (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau. Microglia and astrocytes respond to the abnormal presence of tau protein with induced transposable element (TE) transcription. In this Forum, we discuss new data that link dysregulated TE expression to AD pathogenesis.

Keywords: human endogenous retroviruses; innate immunity; long interspersed nuclear elements type 1; neurodegeneration; retrotransposon; tau.

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Conflict of interest statement

Declaration of interest Teresa Evering is a paid consultant for Tonix Pharmaceuticals. All other authors declare no competing interests in relation to this work.

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