Transposable elements and Alzheimer's disease pathogenesis
- PMID: 36588011
- DOI: 10.1016/j.tins.2022.12.003
Transposable elements and Alzheimer's disease pathogenesis
Abstract
Alzheimer's disease (AD) is characterized by the pathological accumulation of amyloid β (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau. Microglia and astrocytes respond to the abnormal presence of tau protein with induced transposable element (TE) transcription. In this Forum, we discuss new data that link dysregulated TE expression to AD pathogenesis.
Keywords: human endogenous retroviruses; innate immunity; long interspersed nuclear elements type 1; neurodegeneration; retrotransposon; tau.
Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Conflict of interest statement
Declaration of interest Teresa Evering is a paid consultant for Tonix Pharmaceuticals. All other authors declare no competing interests in relation to this work.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical