Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Dec 14:13:1062249.
doi: 10.3389/fphar.2022.1062249. eCollection 2022.

Influence of lecithin cholesterol acyltransferase alteration during different pathophysiologic conditions: A 45 years bibliometrics analysis

Hongliang Gao  1   2   3 , Jing Wu  1 , Zhenyu Sun  4 , Furong Zhang  1 , Tianshu Shi  5 , Ke Lu  6 , Dongfu Qian  4 , Zicheng Yin  7 , Yinjuan Zhao  3 , Jian Qin  1 , Bin Xue  1
Affiliations

Influence of lecithin cholesterol acyltransferase alteration during different pathophysiologic conditions: A 45 years bibliometrics analysis

Hongliang Gao et al. Front Pharmacol. .

Erratum in

Abstract

Background: Lecithin cholesterol acyltransferase (LCAT) is an important enzyme responsible for free cholesterol (FC) esterification, which is critical for high density lipoprotein (HDL) maturation and the completion of the reverse cholesterol transport (RCT) process. Plasma LCAT activity and concentration showed various patterns under different physiological and pathological conditions. Research on LCAT has grown rapidly over the past 50 years, but there are no bibliometric studies summarizing this field as a whole. This study aimed to use the bibliometric analysis to demonstrate the trends in LCAT publications, thus offering a brief perspective with regard to future developments in this field. Methods: We used the Web of Science Core Collection to retrieve LCAT-related studies published from 1975 to 2020. The data were further analyzed in the number of studies, the journal which published the most LCAT-related studies, co-authorship network, co-country network, co-institute network, co-reference and the keywords burst by CiteSpace V 5.7. Results: 2584 publications contained 55,311 references were used to analyzed. The number of included articles fluctuated in each year. We found that Journal of lipid research published the most LCAT-related studies. Among all the authors who work on LCAT, they tend to collaborate with a relatively stable group of collaborators to generate several major authors clusters which Albers, J. published the most studies (n = 53). The United States of America contributed the greatest proportion (n = 1036) of LCAT-related studies. The LCAT-related studies have been focused on the vascular disease, lecithin-cholesterol acyltransferase reaction, phospholipid, cholesterol efflux, chronic kidney disease, milk fever, nephrotic syndrome, platelet-activating factor acetylhydrolase, reconstituted lpa-i, reverse cholesterol transport. Four main research frontiers in terms of burst strength for LCAT-related studies including "transgenic mice", "oxidative stress", "risk", and "cholesterol metabolism "need more attention. Conclusion: This is the first study that demonstrated the trends and future development in LCAT publications. Further studies should focus on the accurate metabolic process of LCAT dependent or independent of RCT using metabolic marker tracking techniques. It was also well worth to further studying the possibility that LCAT may qualify as a biomarker for risk prediction and clinical treatment.

Keywords: bibliometrics; emerging trends; lecithin cholesterol acyltransferase; physiological; risk.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Time sequence of relevant studies on LCAT published from 1975 to 2020 in Web of Science Core Collection.
FIGURE 2
FIGURE 2
The dual-map overlay of journals related to LCAT studies. The citing journals were on the left, the cited journals were on the right, and the colored path represents the citation relationship.
FIGURE 3
FIGURE 3
Number of published LCAT-related studies worldwid. The darker the color is, the more the number of published studies.
FIGURE 4
FIGURE 4
Cooperation among countries. The co-country network among the countries that published the LCAT-related studies.
FIGURE 5
FIGURE 5
Cooperation among institutions. The co-institute network among the institutions that published the LCAT-related studies.
FIGURE 6
FIGURE 6
Co-authorship of LCAT-related studies. The co-authorship network that works on LCAT.
FIGURE 7
FIGURE 7
The network of co-cited references clusters. Clusters are labeled in bright red. Key authors are labeled in dark red. The clusters labels and key authors’ labels are located in different outlines with different colors, and the warmer the colors, the closer they are to the latest current. Clusters within the red outline indicate the current research hotspots, that is, rapid increases in citation counts. #, a cluster; hdl, high density lipoprotein.
FIGURE 8
FIGURE 8
Co-authorship and Cited Reference Co-citation analysis in the last 10 years. (A) Co-authorship of LCAT-related studies. (B) Authors with the top 10 number of LCAT-related studies. (C) The network of co-cited references clusters in the last 10 years.
FIGURE 9
FIGURE 9
The keywords with the strongest citation bursts for publications on LCAT-related studies from 1985 to 2020. The red line indicates the time period when the keyword had a burst.
FIGURE 10
FIGURE 10
The timeline map of LCAT-related co-citation clusters. Major clusters are labeled on the right. Landmark keywords are labeled on the timelines.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Anantharamaiah G. M., Jones J. L., Brouillette C. G., Schmidt C. F., Chung B. H., Hughes T. A., et al. (1985). Studies of synthetic peptide analogs of the amphipathic helix. Structure of complexes with dimyristoyl phosphatidylcholine. J. Biol. Chem. 260, 10248–10255. 10.1016/s0021-9258(17)39238-4 - DOI - PubMed
    1. Badeau R. M., Metso J., Kovanen P. T., Lee-Rueckert M., Tikkanen M. J., Jauhiainen M. (2013). The impact of gender and serum estradiol levels on HDL-mediated reverse cholesterol transport. Eur. J. Clin. Invest. 43, 317–323. 10.1111/eci.12044 - DOI - PubMed
    1. Buchko G. W., Treleaven W. D., Dunne S. J., Tracey A. S., Cushley R. J. (1996). Structural studies of a peptide activator of human lecithin-cholesterol acyltransferase. J. Biol. Chem. 271, 3039–3045. 10.1074/jbc.271.6.3039 - DOI - PubMed
    1. Calabresi L., Simonelli S., Gomaraschi M., Franceschini G. (2012). Genetic lecithin:cholesterol acyltransferase deficiency and cardiovascular disease. Atherosclerosis 222, 299–306. 10.1016/j.atherosclerosis.2011.11.034 - DOI - PubMed
    1. Castro G. R., Fielding C. J. (1988). Early incorporation of cell-derived cholesterol into pre-beta-migrating high-density lipoprotein. Biochemistry 27, 25–29. 10.1021/bi00401a005 - DOI - PubMed