Corrigendum: Xiaoyaosan alleviates hippocampal glutamate-induced toxicity in the CUMS rats via NR2B and PI3K/Akt signaling pathway

Abstract

[This corrects the article DOI: 10.3389/fphar.2021.586788.].

Keywords: NR2B; PI3K/Akt pathway; depression; glutamate; hippocampal CA1 region; xiaoyaosan.

FIGURE 5

Xiaoyaosan elevates the expression of MAP2 in the hippocampal CA1 region of CUMS rats (A, original magnifification, ×200) Xiaoyaosan and Xiaoyaosan + Ly294002 promoted MAP2 expression in the CUMS rats. The green color represents MAP2 staining, and the blue color represents nuclear staining (C) Representative images and western blot analysis (D) of western blot assay showing the relative expression of MAP2 (B) Level of MAP2 mRNA in the hippocampal CA1 area of the rats in the treatment and control groups. All data are expressed as the mean ± SD. ^# p < 0.05 compared to the control group; ^* p < 0.05 compared to the vehicle (W) group; ^▲ p < 0.05 compared to the Ly294002 group, n = 6.

FIGURE 8

Xiaoyaosan elevates the expression of P-AKT/AKT in the hippocampal CA1 region of CUMS rats P-AKT/AKT in the hippocampal CA1 region of CUMS rats (A) Representative micrographs of immunohistochemical staining (sections were counterstained with hematoxylin; original magnifification, ×200) and (B) quantitative analysis showing the expression of P-AKT in the hippocampal CA1 region (C). Representative images and western blot analysis (D) of western blot assay showing the relative expression ratio of P-AKT/AKT in the hippocampal CA1 region. All data are expressed as the mean ± SD. ^# p < 0.05 compared to the control group; ^* p < 0.05, compared to the vehicle (W) group; ^▲ p < 0.05 compared to the Ly294002 group, n = 6.