Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Dec 21:2022:4857872.
doi: 10.1155/2022/4857872. eCollection 2022.

Safety and Immunogenicity of Pertussis Vaccine Immunization during Pregnancy: A Meta-Analysis of Randomized Clinical Trials

Aidibai Simayi  1   2 , Liguo Zhu  3   4 , Hui Jin  1   2
Affiliations
Review

Safety and Immunogenicity of Pertussis Vaccine Immunization during Pregnancy: A Meta-Analysis of Randomized Clinical Trials

Aidibai Simayi et al. J Trop Med. .

Abstract

The objective of this meta-analysis is to assess the safety and immunogenicity of maternal pertussis vaccination based on randomized clinical trials. PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Internet, and Wan Fang Database were searched from inception up to the 8th of October 2021, using a protocol registered on PROSPERO with no. 42021287717, and a meta-analysis was conducted. We measured pooled geometric mean concentrations (GMCs) for IgG antibodies against pertussis and the incidence of serious adverse events (SAEs). We identified a total of 522 publications, and after a strict screening, we found that 6 RCTs were eligible for our meta-analysis. GMCs were determined with a standardized mean difference (SMD), and the pooled SMD of anti-PT, anti-FHA, and anti-PRN IgG from cord blood were 0.91 (95% CI: 0.58, 1.24), 1.03 (95% CI: (0.70, 1.35)), and 1.55(95% CI: 1.22, 1.88), respectively. The pooled OR of SAEs of women and infants did not show a statistical difference; the pooled ORs were 1.26 (95% CI: 0.78, 2.05); P = 0.35) and 0.61 (95% CI: 0.37, 1.01); p = 0.053), respectively. Infants of immunized women have significantly higher transplacental antibodies for protection against pertussis disease during the first 2 months of life.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1
Flow chart of the literature searching process.
Figure 2
Figure 2
Forest plots of GMCs for pertussis antibodies in infants from cord blood.
Figure 3
Figure 3
Forest plots of SAEs of women and infants.
See this image and copyright information in PMC

References

    1. Hewlett E. L., Burns D. L., Cotter P. A., et al. Pertussis pathogenesis--what we know and what we don’t know. Journal of Infectious Diseases . 2014;209(7):982–985. doi: 10.1093/infdis/jit639. - DOI - PMC - PubMed
    1. Pertussis vaccines: WHO position paper - september 2015. Weekly Epidemiological Record . 2015;90:433–458. - PubMed
    1. Yeung K. H. T., Duclos P., Nelson E. A. S., Hutubessy R. C. W. An update of the global burden of pertussis in children younger than 5 years: a modelling study. The Lancet Infectious Diseases . 2017;17(9):974–980. doi: 10.1016/S1473-3099(17)30390-0. - DOI - PubMed
    1. Baclic O., Tunis M., Rotondo J. An Advisory Committee Review Advisory Committee on Immunization (NACI) Ottawa, Canada: Public Health Agency of Canada; 2018. Literature Review on Immunization in Pregnancy with Tetanus Toxoid, Reduced Diphtheria Toxoid and Reduced Acellular Pertussis (Tdap) Vaccine: Safety, Immunogenicity and Effectiveness. - PMC - PubMed
    1. Hozbor D., Ulloa-Gutierrez R., Marino C., Wirsing von Konig C. H., Tan T., Forsyth K. Pertussis in Latin America: recent epidemiological data presented at the 2017 global pertussis initiative meeting. Vaccine . 2019;37(36):5414–5421. doi: 10.1016/j.vaccine.2019.07.007. - DOI - PubMed

LinkOut - more resources