A perfect storm: acute portal vein thrombosis in a patient with severe dengue and hemorrhagic manifestations-a case report
- PMID: 36589635
- PMCID: PMC9792920
- DOI: 10.1186/s43066-022-00233-9
A perfect storm: acute portal vein thrombosis in a patient with severe dengue and hemorrhagic manifestations-a case report
Abstract
Background: Dengue constitutes a public health problem in endemic regions. The clinical course can range from asymptomatic to severe expressions. Hemorrhagic manifestations are the most frequently reported complications; on the contrary, thrombotic complications are unusual.
Clinical case: We present the case of an adult patient who presented hemodynamic instability, severe thrombocytopenia, and positive serology for dengue, in whom acute portal vein thrombosis was documented. The possible pathophysiology of thrombocytopenia and thrombosis in dengue is discussed, as well as the dilemmas regarding the treatment of associated hemorrhagic and thrombotic manifestations.
Conclusions: The present case brings up the importance of considering the possibility of thrombotic events in patients with severe dengue. A high degree of suspicion, close assessment of hemostatic function, and quality supportive care are essential to improve outcomes. To our knowledge, this is the first report of dengue-associated portal vein thrombosis.
Keywords: Dengue; Portal vein thrombosis; Thrombocytopenia.
© The Author(s) 2022.
Conflict of interest statement
Competing interestsThe authors declare that they have no competing interests.
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References
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- Organización Mundial de la Salud . Dengue y dengue grave. Oms. 2016. p. 1.
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- INS Boletín Epidemiológico Semanal - Semana epidemiológica 52. Inst Nac Salud- SIVIGILA. 2019;52:28.
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