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. 2022 Dec 17:8:100180.
doi: 10.1016/j.prdoa.2022.100180. eCollection 2023.

Severity of depressive and motor symptoms impacts quality of life in Parkinson's disease patients at an academic movement clinic: A cross-sectional study

Brianne Lacy  1 , Hien J Piotrowski  1 , Richard B Dewey Jr  1 , Mustafa M Husain  1
Affiliations

Severity of depressive and motor symptoms impacts quality of life in Parkinson's disease patients at an academic movement clinic: A cross-sectional study

Brianne Lacy et al. Clin Park Relat Disord. .

Abstract

Introduction: Parkinson's disease (PD) is a neurodegenerative disease with motor and non-motor manifestations that have been previously reported to affect patient quality of life (QoL). Our objective is to investigate the factors that contribute to QoL in a cohort of PD patients receiving care at a major academic institution.

Methods: In this cross-sectional study of 124 participants (71.77% male, mean age 65.20, mean UPDRS-III score 11.25), we analyzed if certain clinical features such as UPDRS-III, QIDS-C, and total disease duration contributed to QoL as measured by two different metrics (PDQ-39 and EQ-5D) in PD patients at a university Movement Disorders Clinic.

Results: Motor symptoms of PD, with the exception of tremor, as well as depression and specific depressive symptoms were significantly and positively correlated with lower QoL metrics for patients with Parkinson's, with total depressive symptom severity (QIDS-C16 Total score) contributing most to QoL scores. Of the specific depressive and motor symptoms, anhedonia and rigidity contributed the most to QoL. Disease duration was significantly correlated with lower QoL for participants with Parkinson's according to the QoL metric PDQ-39 but not ED-5D. Parkinson's patients with access to high-quality healthcare are at risk for having diminished QoL due to both depressive and motor symptoms.

Conclusion: While severity of motor symptoms certainly impacted QoL in our cohort, our findings suggest that depressive symptoms contribute more to impaired QoL than severe motor symptoms do. This phenomenon suggests that concomitant depression in PD as well as one's psychological adjustment to disability may have a greater impact on QoL than severe motor symptoms.

Keywords: Academic institution; Depression; Movement disorders; Parkinson’s disease; Quality of Life.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Factors contributing to Parkinson’s Disease Questionnaire-39 (PDQ-39) Summary Index. X-axis represents the clinical features of interest, including QIDS and UPDRS composites and disease duration. *p-value < 0.05. ρ, Spearman correlation coefficient; UPDRS-III, Unified Parkinson’s Disease Rating Scale Part III; QIDS-C16, Quick Inventory of Depressive Symptoms - Clinician Rated.
Fig. 2
Fig. 2
Factors contributing to EuroQoL (EQ-5D) Index. X-axis represents the clinical features of interest, including QIDS and UPDRS composites and disease duration. *p-value < 0.05. ρ, Spearman correlation coefficient; UPDRS-III, Unified Parkinson’s Disease Rating Scale Part III; QIDS-C16, Quick Inventory of Depressive Symptoms - Clinician Rated.
Fig. 3
Fig. 3
Correlation coefficients between PDQ-39 subdomains and depressive symptoms, motor symptoms, and disease duration. *p-value < 0.05. UPDRS-III, Unified Parkinson’s Disease Rating Scale Part III; QIDS-C16, Quick Inventory of Depressive Symptoms - Clinician Rated; PDQ-39, Parkinson’s Disease Questionnaire-39.
See this image and copyright information in PMC

References

    1. Marras C., Beck J.C., Bower J.H., Roberts E., Ritz B., Ross G.W., Abbott R.D., Savica R., Van Den Eeden S.K., Willis A.W., Tanner C.M., P.G. Parkinson’s Foundation Prevalence of Parkinson's disease across North America. NPJ Parkinsons Dis. 2018;4 21-21. - PMC - PubMed
    1. Berardi A., Regoli E., Tofani M., Valente D., Fabbrini G., Fabbrini A., Ruggieri M., Panuccio F., Galeoto G. Tools to assess the quality of life in patients with Parkinson's disease: a systematic review. Expert Rev. Pharmacoecon. Outcomes Res. 2021;21(1):55–68. - PubMed
    1. Zhao N., Yang Y., Zhang L., Zhang Q., Balbuena L., Ungvari G.S., Zang Y.F., Xiang Y.T. Quality of life in Parkinson's disease: A systematic review and meta-analysis of comparative studies. CNS Neurosci. Ther. 2021;27(3):270–279. - PMC - PubMed
    1. Kasten M., Kertelge L., Tadic V., Bruggemann N., Schmidt A., van der Vegt J., Siebner H., Buhmann C., Lencer R., Kumar K.R., Lohmann K., Hagenah J., Klein C. Depression and quality of life in monogenic compared to idiopathic, early-onset Parkinson's disease. Mov. Disord. 2012;27(6):754–759. - PubMed
    1. Santos-García D., de Deus Fonticoba T., Suárez Castro E., Aneiros Díaz A., Cores Bartolomé C., Feal Panceiras M.J., Paz González J.M., Valdés Aymerich L., García Moreno J.M., Blázquez Estrada M., Jesús S., Mir P., Aguilar M., Planellas L.L., García Caldentey J., Caballol N., Legarda I., Cabo López I., López Manzanares L., Ávila Rivera M.A., Catalán M.J., López Díaz L.M., Borrué C., Álvarez Sauco M., Vela L., Cubo E., Martínez Castrillo J.C., Sánchez Alonso P., Alonso Losada M.G., López Ariztegui N., Gastón I., Pascual-Sedano B., Seijo M., Ruíz Martínez J., Valero C., Kurtis M., González Ardura J., Prieto Jurczynska C., Martinez-Martin P. Quality of life and non-motor symptoms in Parkinson's disease patients with subthreshold depression. J. Neurol. Sci. 2020;418 - PubMed

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