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. 2022 Dec 24:30:100671.
doi: 10.1016/j.lanwpc.2022.100671. eCollection 2023 Jan.

Nirmatrelvir-ritonavir treatment on SARS-CoV-2 viral dynamics in high altitude habitants

Aili Lu  1   2 , Xuefu Zhou  3   4 , Daoping Han  2 , Lu Tang  5 , Xuping Rong  2 , Yulan Zheng  6 , Peng Hong  5   7   8
Affiliations

Nirmatrelvir-ritonavir treatment on SARS-CoV-2 viral dynamics in high altitude habitants

Aili Lu et al. Lancet Reg Health West Pac. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Nirmatrelvir-ritonavir treatment on SARS-CoV-2 viral dynamics in the upper respiratory tract. (A) Viral load dynamics in upper respiratory tracts of SARS-CoV-2 infected individuals treated with or without nirmatrelvir-ritonavir. Time zero corresponds to the time at which a patient first tested positive for SARS-CoV-2 infection. Dots and error bars represent geometric means and 95% confidence intervals (CI). Horizontal dashed line indicates the limit of detection of qRT-PCR assay (100 copies/ml). Sample number at each data point is listed below the plot. (B) Cumulative event plots of time-to-viral clearance according to nirmatrelvir-ritonavir treatment status. Hazard ratios (HR) and CI were estimated by Cox proportional hazard model after adjusting for confounders listed in panel C. (C) Forest plots showing Cox proportional hazard model analysis of indicated factors with time-to-viral clearance as the dependent variable (n = 314). Adjusted HR of each factor is expressed on log axis. Squares and error bars represented HR and 95% CI. Directional trends were labeled under the X axis.
See this image and copyright information in PMC

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