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Review
. 2022 Dec 15:13:1070750.
doi: 10.3389/fimmu.2022.1070750. eCollection 2022.

Immunity: Psoriasis comorbid with atherosclerosis

Chunping Liu  1   2   3   4 , Huiqi Chen  1   3 , Yanjiao Liu  1   3 , Haiding Huang  1   3 , Wanling Yu  1   3 , Tingting Du  1   3 , Xinyao Long  1   3 , Xinming Chen  1   3 , Zhijun Chen  1   3 , Sien Guo  1   3 , Jinxin Li  1   3 , Zebo Jiang  5 , Lei Wang  1   3 , Chuanjian Lu  1   2   3
Affiliations
Review

Immunity: Psoriasis comorbid with atherosclerosis

Chunping Liu et al. Front Immunol. .

Abstract

Psoriasis is an immune-mediated, persistent inflammatory disease with a genetic predisposition, and the involvement of multiple organs in psoriasis remains indicative of systemic disease. Atherosclerosis (AS) is a common complication of patients with severe or prolonged psoriasis. The specific pathogenesis of psoriasis is still unclear. Current studies suggest that psoriasis is a polygenic genetic disease with the interaction of multiple factors such as heredity and environment. Keratinocytes are proliferated through immune-mediated inflammatory pathway, which leads to cell activation, infiltration of dermis cells and release of inflammatory factors. Activation of inflammatory cells and pro-inflammatory factors play an important role in the progression of psoriasis and atherosclerosis. Studies have found that there is a close relationship between psoriasis and atherosclerosis, and systemic inflammation may be the common feature of psoriasis and AS. This paper attempts to explore the possibility of the relationship between psoriasis and atherosclerotic comorbidities from the aspects of potential epidemiology and immune mechanism, in order to provide some reference for the subsequent scientific research.

Keywords: atherosclerosis; comorbidity; immunology; inflammation; psoriasis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The immune mechanism of Psoriasis comorbidities with atherosclerosis.
See this image and copyright information in PMC

References

    1. Rendon A, Schäkel K. Psoriasis pathogenesis and treatment. Int J Mol Sci (2019) 20(6):1475. doi: 10.3390/ijms20061475 - DOI - PMC - PubMed
    1. O. World Health . Global report on psoriasis. Geneva: World Health Organization; (2016).
    1. N.P. Foundation . Come together for world psoriasis day (2020). Available at: https://www.psoriasis.org/advance/come-together-for-world-psoriasis-day/.
    1. Griffiths CEM, van der Walt JM, Ashcroft DM, Flohr C, Naldi L, Nijsten T, et al. . The global state of psoriasis disease epidemiology: a workshop report. Br J Dermatol (2017) 177(1):e4–7. doi: 10.1111/bjd.15610 - DOI - PMC - PubMed
    1. Armstrong AW, Read C. Pathophysiology, clinical presentation, and treatment of psoriasis: A review. Jama (2020) 323(19):1945–60. doi: 10.1001/jama.2020.4006 - DOI - PubMed

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