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. 2023 Jan;74(1):55-64.
doi: 10.1007/s00105-022-05091-5.

[Nailfold capillaroscopy-Principles and clinical application]

[Article in German]
R Hasseli-Fräbel  1 , W Hermann  2 , O Sander  3 , K Triantafyllias  4
Affiliations

[Nailfold capillaroscopy-Principles and clinical application]

[Article in German]
R Hasseli-Fräbel et al. Dermatologie (Heidelb). 2023 Jan.

Abstract
in English, German

Nailfold capillaroscopy is a rapid and easily applicable differential diagnostic technique that allows direct visualization of the microcirculation. Abnormal findings in nailfold capillaroscopy are closely associated with connective tissue diseases, such as systemic sclerosis. The clinical manifestation of impaired microcirculation is Raynaud's phenomenon, which is a classical symptom of connective tissue diseases. Nailfold capillaroscopy is increasingly used in various fields of medicine, therefore it is important to define methods for the acquisition and analysis of the results of nailfold capillary and to have a uniform definition of abnormal capillaries. This article discusses image acquisition and analysis, various capillaroscopic techniques, normal and abnormal capillaroscopic features and their significance, scoring systems and reliability of image acquisition and interpretation.

Die Kapillarmikroskopie ist ein schnell und unkompliziert anwendbares differenzialdiagnostisches Tool, mit dem v. a. zwischen einem primären und sekundären Raynaud-Phänomen unterschieden werden kann. Bei verschiedenen Kollagenosen, vorrangig der systemischen Sklerose, ist sie sowohl zur Diagnostik als auch zur Aktivitäts- und Verlaufsbeurteilung unerlässlich. In der Kapillarmikroskopie feststellbare mikroangiopathische Muster lassen sich darüber hinaus auch bei weiteren Erkrankungen feststellen. In dieser Arbeit werden die Grundlagen der Untersuchung, deren Anwendung und klinische Relevanz dargestellt.

Keywords: Connective tissue disease; Inflammatory rheumatic diseases; Microangiopathy; Raynaud’s phenomenon; Systemic sclerosis.

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References

    1. Hermann W. Kapillarmikroskopie. Z Rheumatol. 2016;75(6):586–590. doi: 10.1007/s00393-016-0150-y. - DOI - PubMed
    1. Dima A, Berza I, Popescu DN, Parvu MI. Nailfold capillaroscopy in systemic diseases: short overview for internal medicine. Rom J Intern Med. 2021;59(3):201–217. - PubMed
    1. Smith V, Herrick AL, Ingegnoli F, et al. EULAR Study Group on Microcirculation in Rheumatic Diseases and the Scleroderma Clinical Trials Consortium Group on Capillaroscopy. Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud’s phenomenon and systemic sclerosis. Autoimmun Rev. 2020;19(3):102458. doi: 10.1016/j.autrev.2020.102458. - DOI - PubMed
    1. Cutolo M, Sulli A, Smith V. How to perform and interpret capillaroscopy. Best Pract Res Clin Rheumatol. 2013;27(2):237–248. doi: 10.1016/j.berh.2013.03.001. - DOI - PubMed
    1. Geyer M, Vasile M, Hermann W. Kapillarmikroskopie. Z Rheumatol. 2014;73(2):149–160. doi: 10.1007/s00393-013-1314-7. - DOI - PubMed

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