Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Dec;54(4):1185-1192.
doi: 10.1007/s12029-022-00908-x. Epub 2023 Jan 3.

Contemporary Outcomes for the Curative Treatment of Colorectal Cancer Pulmonary Metastases

Dima Hammoud  1 , Matthieu Glorion  2 , Pietro Genova  1 , Mostapha El Hajjam  3   4 , Jalal Assouad  5 , Frédérique Peschaud  1   3 , Cindy Neuzillet  6 , Denis Debrosse  5 , Renato Micelli Lupinacci  7   8
Affiliations

Contemporary Outcomes for the Curative Treatment of Colorectal Cancer Pulmonary Metastases

Dima Hammoud et al. J Gastrointest Cancer. 2023 Dec.

Abstract

Purpose: Treatment of pulmonary metastases (PM) from colorectal cancer (CRC) is the standard of care by several guidelines from Europe and the USA, but the validity of this strategy has been recently questioned, and the available evidence supporting this strategy is weak. We report the outcomes of a curative intent strategy in a very recent and homogenous series of patients.

Methods: We did a retrospective review of all curative intent surgical or ablative treatment of PM from CRC performed consecutively in 3 French institutions from January 2015 to December 2019. Demographics, clinicopathological, and molecular characteristics were evaluated. Cox regression models were used to identify prognostic factors related to local recurrence and disease-free survival.

Results: Records from 152 patients were reviewed. One-hundred thirty-five patients (88%) had surgical metastasectomy. Median age was 67 years. Most of the patients had a single lesion (66%), and 16% had synchronous PM. Eighty-one patients (53%) experienced recurrence, and the thorax was the most common site of recurrence. Median disease-free survival and overall survival were 35 months and 78 months after PM treatment. At the end of the study, only 17% of the patients died. Pulmonary tumor burden was correlated with disease-free survival in univariate analysis, but multivariate analysis did not find any prognostic factor independently associated with local recurrence or survival.

Conclusion: Our finds corroborate existing recommendation for the invasive treatment of PM from CRC in selected patients.

Keywords: Colorectal cancer; Metastases; Pulmonary metastasis; Radiofrequency ablation; Thoracic surgery.

PubMed Disclaimer

References

    1. Mattiuzzi C, Lippi G. Current cancer epidemiology: J Epidemiol Glob Health. 2019;9:217. - PubMed - PMC
    1. Davini F, Ricciardi S, Zirafa CC, Romano G, Alì G, Fontanini G, et al. Lung metastasectomy after colorectal cancer: prognostic impact of resection margin on long term survival, a retrospective cohort study. Int J Colorectal Dis. 2020;35:9–18. - DOI - PubMed
    1. Parnaby CN, Bailey W, Balasingam A, Beckert L, Eglinton T, Fife J, et al. Pulmonary staging in colorectal cancer: a review. Colorectal Dis Off J Assoc Coloproctology G B Irel. 2012;14:660–70.
    1. Ahtiainen M, Elomaa H, Väyrynen JP, Wirta E-V, Kuopio T, Helminen O, et al. Immune contexture of MMR-proficient primary colorectal cancer and matched liver and lung metastases. Cancers. 2021;13:1530. - DOI - PubMed - PMC
    1. Labianca R, Beretta GD, Kildani B, Milesi L, Merlin F, Mosconi S, et al. Colon cancer. Crit Rev Oncol Hematol. 2010;74:106–33. - DOI - PubMed

LinkOut - more resources