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Meta-Analysis
. 2022 Dec 23;101(51):e32391.
doi: 10.1097/MD.0000000000032391.

Aerobic exercise combined with resistance exercise training improves cardiopulmonary function and blood lipid of patients with breast cancer: A systematic review and meta-analysis

Lingfeng Kong  1 , Run Gao  2
Affiliations
Meta-Analysis

Aerobic exercise combined with resistance exercise training improves cardiopulmonary function and blood lipid of patients with breast cancer: A systematic review and meta-analysis

Lingfeng Kong et al. Medicine (Baltimore). .

Abstract

Background: To compare the therapy effects following the aerobic exercise combined with resistance exercise training (AET + RET) and common care treatment for patients with breast cancer.

Methods: Articles about the effects of AET + RET on the breast cancer patients in 4 online databases were searched. The differences of cardiopulmonary function, blood pressure, blood lipid, and body mass index between the AET + RET treatment and the usual care treatment were compared.

Results: Totally, 8 articles were involved into the meta-analysis. The qualities of the 8 articles were medium. The combination results showed that AET + RET increased the VO2peak (weighted mean difference (WMD) = 2.93 mL/kg/min; 95% CI: 0.38, 5.49; P = .02) and VO2max (WMD = 6.98 mL/kg/min; 95% CI: 2.04, 15.92; P = .01), demonstrating its improving effects in cardiopulmonary function. Moreover, the AET + RET decreased the TG (WMD = -57.95 mg/dL; 95% CI: -112.25, -3.64; P = .04), demonstrating its improving effects in blood lipid. While or the HRpeak, RERpeak, systolic blood pressure, diastolic blood pressure, high-density lipoprotein cholesterol, and body mass index, there are no significant differences between the AET + RET and usual care treatment (P < .05).

Conclusion: Our results demonstrated that AET + RET can significantly improve the cardiopulmonary function and blood lipid for breast cancer patients.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1.
Figure 1.
The process and results of literature retrieval.
Figure 2.
Figure 2.
Forest plots comparing the differences in cardiorespiratory parameters between aerobic exercise training combined with resistance exercise training (AET + RET) and unral care (UC) groups. (A) The results of peak oxygen uptake (VO2peak); (B) The results of maximal oxygen consumption (VO2max); (C) The results of peak heart rate (HRpeak); (D) The results of peak respiratory exchange ratio (RERpeak). Experimental group represent the AET + RET group, and the control group represent the UC group (the same below).
Figure 3.
Figure 3.
Forest plots comparing the differences in blood pressure between AET + RET and UC groups. (A) The results of systolic blood pressure (SBP); (B) The results of diastolic blood pressure (DBP).
Figure 4.
Figure 4.
Forest plots comparing the differences in serum lipids between AET + RET and UC groups. (A) The results of high-density lipoprotein cholesterol (HDL-C); (B) The results of triglycerides (TG).
Figure 5.
Figure 5.
Forest plots comparing the differences in body mass index (BMI) between AET + RET and UC groups.
See this image and copyright information in PMC

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